Llanes C, Michel-Briand Y, Couturier M, Thouverez M, Bailly C
CNRS URA 531, Faculté de Médecine, Université de Franche-Comté, Besançon.
C R Seances Soc Biol Fil. 1989;183(3):240-6.
We studied the effects of ciprofloxacin on 73 strains of Serratia marcescens. In the first place, we have tested their plasmidic content: 76% of Serratia marcescens strains contained plasmids by electrophoresis, and 29% of these plasmids were self-transmissible by conjugation. Secondly, we studied the plasmid stability with regard to ciprofloxacin. We obtained a spontaneous cure with 19% of plasmids, and ciprofloxacin, at very low concentrations (0.4 mg/l), increased the rate of cure and more efficiently than novobiocin, a compound used as a known curing agent.
我们研究了环丙沙星对73株粘质沙雷氏菌的影响。首先，我们检测了它们的质粒含量：通过电泳，76%的粘质沙雷氏菌菌株含有质粒，其中29%的质粒可通过接合作用自身转移。其次，我们研究了质粒对环丙沙星的稳定性。我们发现19%的质粒可自发消除，而极低浓度（0.4毫克/升）的环丙沙星可提高消除率，且比用作已知消除剂的新生霉素更有效。
