Baquerizo Bernarda Viteri, Peters Craig A
Maimonides Medical Center 4802 Tenth Avenue, Brooklyn, NY 11219 USA.
Sheikh Zayed Institute for Pediatric Surgical Innovation, Children's National Medical Center 111 Michigan Avenue, NW, Washington, DC 20010 USA.
F1000Prime Rep. 2014 Nov 4;6:104. doi: 10.12703/P6-104. eCollection 2014.
The use of continuous antibiotic prophylaxis (CAP) was critical in the evolution of vesicoureteral reflux (VUR) from a condition in which surgery was the standard of treatment to its becoming a medically managed condition. The efficacy of antibiotic prophylaxis in the management of VUR has been challenged in recent years, and significant confusion exists as to its clinical value. This review summarizes the critical factors in the history, use, and investigation of antibiotic prophylaxis in VUR. This review provides suggestions for assessing the potential clinical utility of prophylaxis.
在膀胱输尿管反流（VUR）从以手术为标准治疗手段的疾病演变为可通过药物治疗的疾病的过程中，持续抗生素预防（CAP）的应用起到了关键作用。近年来，抗生素预防在VUR治疗中的疗效受到了质疑，其临床价值也存在很大争议。本综述总结了VUR抗生素预防的历史、应用及研究中的关键因素。本综述为评估预防的潜在临床效用提供了建议。
