Sen Hadice Selimoglu, Abakay Özlem, Cetincakmak Mehmet Güli, Sezgi Cengizhan, Yilmaz Süreyya, Demir Melike, Taylan Mahsuk, Gümüs Hatice
Department of Pulmonology, Dicle University Medical Faculty, 21281 Diyarbakir, Turkey.
Department of Radiodiagnostics, Dicle University Medical Faculty, 21281 Diyarbakir, Turkey.
Biomed Res Int. 2014;2014:470295. doi: 10.1155/2014/470295. Epub 2014 Dec 14.
This study aimed to investigate the currency of computerized tomography pulmonary angiography-based parameters as pulmonary artery obstruction index (PAOI), as well as right ventricular diameters for pulmonary embolism (PE) risk evaluation and prediction of mortality and intensive care unit (ICU) requirement.
The study retrospectively enrolled 203 patients hospitalized with acute PE. PAOI was calculated according to Qanadli score.
Forty-three patients (23.9%) were hospitalized in the ICU. Nineteen patients (10.6%) died during the 30-day follow-up period. The optimal cutoff value of PAOI for PE 30th day mortality and ICU requirement were found as 36.5% in ROC curve analysis. The pulmonary artery systolic pressure had a significant positive correlation with right/left ventricular diameter ratio (r = 0.531, P < 0.001), PAOI (r = 0.296, P < 0.001), and pulmonary artery diameter (r = 0.659, P < 0.001). The patients with PAOI values higher than 36.5% have a 5.7-times increased risk of death.
PAOI is a fast and promising parameter for risk assessment in patients with acute PE. With greater education of clinicians in this radiological scoring, a rapid assessment for diagnosis, clinical risk evaluation, and prognosis may be possible in emergency services without the need for echocardiography.
本研究旨在探讨基于计算机断层扫描肺动脉造影的参数作为肺动脉阻塞指数(PAOI)以及右心室直径在评估肺栓塞(PE)风险、预测死亡率和重症监护病房(ICU)需求方面的适用性。
本研究回顾性纳入了203例急性PE住院患者。PAOI根据卡纳德利评分计算。
43例患者(23.9%)入住ICU。19例患者(10.6%)在30天随访期内死亡。ROC曲线分析发现,PAOI用于PE 30天死亡率和ICU需求的最佳截断值为36.5%。肺动脉收缩压与右/左心室直径比(r = 0.531,P < 0.001)、PAOI(r = 0.296,P < 0.001)和肺动脉直径(r = 0.659,P < 0.001)呈显著正相关。PAOI值高于36.�%的患者死亡风险增加5.7倍。
PAOI是急性PE患者风险评估的一个快速且有前景的参数。随着临床医生对这种放射学评分的更多了解,在急诊服务中无需超声心动图即可进行快速诊断评估、临床风险评估和预后判断。