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阿达木单抗治疗与克罗恩病相关的化脓性汗腺炎。

Adalimumab treatment for hidradenitis suppurativa associated with Crohn's disease.

作者信息

Diamantova Dominika, Lomickova Iva, Cetkovska Petra

机构信息

Dominka Diamantova, MD, Department of Dermatology and Venereology, Military Hospital, Sišilovo nam. 7, Olomouc, Czech Republic;

出版信息

Acta Dermatovenerol Croat. 2014;22(4):291-3.

PMID:25580790
Abstract

Hidradenitis suppurativa (HS) is a chronic, inflammatory disease characterized by recurring abscesses, nodules, and fistulas predominantly in the area of the groin and axillae. The association between HS and Crohn's disease (CD) has already been documented. We report on a case of a patient with CD associated HS, refractory to multiple local and systemic agents.A complete resolution of both diseases was finally achieved after treatment with adalimumab. Our case report supports the co-occurrence of both diseases and suggests that adalimumab approved for CD might also be a safe and effective therapeutic option in the treatment of HS.

摘要

化脓性汗腺炎(HS)是一种慢性炎症性疾病,其特征主要为腹股沟和腋窝区域反复出现脓肿、结节和瘘管。HS与克罗恩病(CD)之间的关联已有文献记载。我们报告了1例患有CD相关HS的患者,该患者对多种局部和全身用药均难治。在用阿达木单抗治疗后,两种疾病最终均完全缓解。我们的病例报告支持这两种疾病同时存在,并表明已获批用于CD的阿达木单抗在治疗HS时可能也是一种安全有效的治疗选择。

相似文献

1
Adalimumab treatment for hidradenitis suppurativa associated with Crohn's disease.阿达木单抗治疗与克罗恩病相关的化脓性汗腺炎。
Acta Dermatovenerol Croat. 2014;22(4):291-3.
2
Hidradenitis suppurativa in Crohn's disease during adalimumab therapy: a paradox?阿达木单抗治疗克罗恩病期间出现化脓性汗腺炎:自相矛盾?
Acta Dermatovenerol Alp Pannonica Adriat. 2017 Mar;26(1):21-23. doi: 10.15570/actaapa.2017.6.
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Successful treatment of hidradenitis suppurativa in the setting of Crohn disease with combination adalimumab and ustekinumab.阿达木单抗和优特克单抗联合治疗克罗恩病合并化脓性汗腺炎取得成功。
Dermatol Online J. 2019 Sep 15;25(9):13030/qt0hw2w4nr.
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Hidradenitis suppurativa and Crohn's disease: two cases that support an association.化脓性汗腺炎与克罗恩病:支持两者存在关联的两例病例
Acta Dermatovenerol Alp Pannonica Adriat. 2010 Oct;19(3):23-5.
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Clinical experience of the use of adalimumab in the management of hidradenitis suppurativa. Comparison of response rates with Crohn disease.阿达木单抗用于治疗化脓性汗腺炎的临床经验。与克罗恩病的缓解率比较。
Actas Dermosifiliogr. 2016 Sep;107 Suppl 2:43-50. doi: 10.1016/S0001-7310(17)30008-X.
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Two Cases of Paradoxical Hidradenitis Suppurativa while on Adalimumab.两例使用阿达木单抗期间出现的反常性化脓性汗腺炎病例。
Case Rep Gastroenterol. 2016 May 19;10(1):88-94. doi: 10.1159/000444442. eCollection 2016 Jan-Apr.
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Hidradenitis suppurativa and Crohn's disease: response to treatment with infliximab.化脓性汗腺炎与克罗恩病:英夫利昔单抗治疗反应
Inflamm Bowel Dis. 2001 Nov;7(4):323-6. doi: 10.1097/00054725-200111000-00008.
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HiSCR (Hidradenitis Suppurativa Clinical Response): a novel clinical endpoint to evaluate therapeutic outcomes in patients with hidradenitis suppurativa from the placebo-controlled portion of a phase 2 adalimumab study.化脓性汗腺炎临床反应(HiSCR):一种用于评估阿达木单抗2期研究安慰剂对照部分中化脓性汗腺炎患者治疗效果的新型临床终点。
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Clinical response rate and flares of hidradenitis suppurativa in the treatment with adalimumab.阿达木单抗治疗化脓性汗腺炎的临床应答率和病情恶化。
Clin Exp Dermatol. 2020 Jun;45(4):438-444. doi: 10.1111/ced.14127. Epub 2019 Dec 24.
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Hidradenitis suppurativa and perianal Crohn disease: differential diagnosis.化脓性汗腺炎与肛周克罗恩病:鉴别诊断
Actas Dermosifiliogr. 2016 Sep;107 Suppl 2:27-31. doi: 10.1016/S0001-7310(17)30006-6.

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Biomedicines. 2025 Jul 27;13(8):1833. doi: 10.3390/biomedicines13081833.
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Management of Hidradenitis Suppurativa in Special Populations: A Narrative Review.特殊人群化脓性汗腺炎的管理:一项叙述性综述
Dermatol Ther (Heidelb). 2025 Jun 20. doi: 10.1007/s13555-025-01457-4.
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Adalimumab, Ustekinumab, and Secukinumab in the Management of Hidradenitis Suppurativa: A Review of the Real-Life Experience.
阿达木单抗、优特克单抗和司库奇尤单抗治疗化脓性汗腺炎:真实世界经验综述
Clin Cosmet Investig Dermatol. 2023 Jan 19;16:135-148. doi: 10.2147/CCID.S391356. eCollection 2023.
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Systematic review of immunomodulatory therapies for hidradenitis suppurativa.化脓性汗腺炎免疫调节疗法的系统评价
Biologics. 2019 May 13;13:53-78. doi: 10.2147/BTT.S199862. eCollection 2019.
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North American clinical management guidelines for hidradenitis suppurativa: A publication from the United States and Canadian Hidradenitis Suppurativa Foundations: Part II: Topical, intralesional, and systemic medical management.北美化脓性汗腺炎临床管理指南:美国和加拿大化脓性汗腺炎基金会联合发布:第二部分:局部、皮损内和全身医学治疗。
J Am Acad Dermatol. 2019 Jul;81(1):91-101. doi: 10.1016/j.jaad.2019.02.068. Epub 2019 Mar 11.