Jabre Joe F, Pitt Matthew C, Deeb Jacquie, Chui Kenneth K H
*Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, U.S.A.; †Department of Clinical Neurophysiology, Great Ormond Street Hospital for children NHS Foundation Trust, London, United Kingdom; ‡Department of Neurophysiology, Queen's Hospital, Barking, Havering and Redbridge University Hospitals NHS Trust, London, United Kingdom; and §Department of Public Health and Community Medicine, Tufts University School of Medicine, Boston, Massachusetts, U.S.A.
J Clin Neurophysiol. 2015 Jun;32(3):265-70. doi: 10.1097/WNP.0000000000000161.
Collecting reference values in subpopulations such as infants and children can pose a daunting challenge to gather through epidemiologic studies. The authors propose to evaluate a method the authors refer to as extrapolated norms (e-norms) to derive Stimulated Single Fiber EMG jitter reference values from the laboratory data of pediatric and adult cohorts. Single Fiber EMG studies are considered the gold standard test for evaluation of neuromuscular transmission disorders.
Data that lie in the plateau part of an inverted S curve derived from sorted jitter data were used to calculate descriptive statistics for pediatric and adult e-norms jitter.
The e-norms derived jitter was 22 ± 2.83 μs for our pediatric and 21 ± 2.79 μs for our adult cohort. Our adult e-norms values compared favorably with the 22 ± 1.99 μs published jitter range derived from a healthy adult cohort.
The e-norms method the authors describe seems to be useful in recovering reference ranges when such values are difficult to obtain, such as in a pediatric subpopulation.
通过流行病学研究收集婴儿和儿童等亚人群的参考值可能是一项艰巨的挑战。作者提议评估一种他们称为外推规范（e规范）的方法，以从儿科和成人队列的实验室数据中得出刺激单纤维肌电图（EMG）抖动参考值。单纤维肌电图研究被认为是评估神经肌肉传递障碍的金标准测试。
使用从排序后的抖动数据得出的倒S曲线平台部分的数据来计算儿科和成人e规范抖动的描述性统计量。
我们儿科队列通过e规范得出的抖动为22±2.83微秒，成人群列为21±2.79微秒。我们的成人e规范值与从健康成人队列得出的已发表抖动范围22±1.99微秒相比具有优势。
作者描述的e规范方法在难以获得此类值时，如在儿科亚人群中，似乎有助于恢复参考范围。
