Pitt Matthew C, Jabre Joe F
Department of Clinical Neurophysiology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, WC1N 3JH, UK.
Department of Neurology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA.
Muscle Nerve. 2017 Jan;55(1):51-54. doi: 10.1002/mus.25191. Epub 2016 Oct 18.
The diagnosis of myasthenia gravis in very young infants is a challenging one. In young infants, stimulated single-fiber electromyography (StimSFEMG) is the most appropriate technique, but it has serious limitations due to the absence of reference values in this subpopulation. Here we present our efforts to derive a reference range of jitter in a patient cohort of infants <3 years of age using the extrapolated norms, or e-norms, technique.
The e-norms method was used to calculate jitter mean consecutive difference (MCD) descriptive statistics for children <3 years of age.
The e-norms derived jitter upper MCD limit was 45 μs in children <1 year, 33 μs in those <2 years, and 26 in those <3 years of age.
In the absence of jitter reference values for the very young, the e-norms method can be used as an alternative to derive these values from laboratory cohorts. Muscle Nerve 55: 51-54, 2017.
诊断非常年幼婴儿的重症肌无力颇具挑战性。对于年幼婴儿，刺激单纤维肌电图（StimSFEMG）是最合适的技术，但由于该亚人群缺乏参考值，其存在严重局限性。在此，我们展示了我们利用外推规范（或e规范）技术，在3岁以下婴儿患者队列中得出抖动参考范围的努力。
采用e规范方法计算3岁以下儿童抖动平均连续差值（MCD）描述性统计量。
e规范得出的抖动MCD上限在1岁以下儿童中为45微秒，2岁以下儿童中为33微秒，3岁以下儿童中为26微秒。
在非常年幼者缺乏抖动参考值的情况下，e规范方法可作为从实验室队列得出这些值的替代方法。《肌肉与神经》55: 51 - 54, 2017年。
