Tomita Tetsu, Sato Yasushi, Nakagami Taku, Tsuchimine Shoko, Kaneda Ayako, Kaneko Sunao, Nakamura Kazuhiko, Yasui-Furukori Norio
Department of Neuropsychiatry, Graduate School of Medicine, Hirosaki University, Hirosaki, Japan.
Clin Neuropharmacol. 2015 Jan-Feb;38(1):6-10. doi: 10.1097/WNF.0000000000000058.
We investigated the effects of age on the association between early and eventual responses to paroxetine treatment in patients with major depressive disorder (MDD).
Eighty-nine patients with MDD were administered paroxetine and completed the 6-week protocol. On the basis of our previous study, we defined early responders as those patients with the Montgomery-Asberg Depression Rating Scale (MADRS) improvements higher than 35% at 2 weeks and responders as those patients with MADRS improvements higher than 50% at 6 weeks. The participants were divided into 4 groups in accordance with their responses: early response responders, early response nonresponders, nonearly response responders (NER-Rs), and nonearly response nonresponders (NER-NRs). Demographic data and the MADRS scores between the early response responders and the early response nonresponders and between the NER-Rs and the NER-NRs were compared. We used a receiver operating characteristic (ROC) curve to analyze age to determine the cutoff points for distinguishing responders and nonresponders in early and nonearly responders.
There was a significant difference in age between the NER-Rs and the NER-NRs, with the NER-Rs being younger than the NER-NRs. The threshold for the response in the early responders was 42 years old. The area under the curve of the ROC curve of the early responders was 0.548. The threshold for the response of the nonearly responders was 55 years old. The area under the curve of the ROC curve of the early responders was 0.733.
The effects of age on the association between the responsiveness in the early phase of antidepressant treatment and the eventual response were identified in patients with MDD.
我们研究了年龄对重度抑郁症（MDD）患者帕罗西汀治疗早期反应与最终反应之间关联的影响。
89例MDD患者服用帕罗西汀并完成6周方案。根据我们之前的研究，我们将早期反应者定义为在2周时蒙哥马利-阿斯伯格抑郁评定量表（MADRS）改善高于35%的患者，将反应者定义为在6周时MADRS改善高于50%的患者。参与者根据其反应分为4组：早期反应反应者、早期反应无反应者、非早期反应反应者（NER-Rs）和非早期反应无反应者（NER-NRs）。比较了早期反应反应者与早期反应无反应者之间以及NER-Rs与NER-NRs之间的人口统计学数据和MADRS评分。我们使用受试者工作特征（ROC）曲线分析年龄，以确定区分早期和非早期反应者中反应者和无反应者的临界点。
NER-Rs和NER-NRs之间的年龄存在显著差异，NER-Rs比NER-NRs年轻。早期反应者的反应阈值为42岁。早期反应者的ROC曲线下面积为0.548。非早期反应者的反应阈值为55岁。早期反应者的ROC曲线下面积为0.733。
在MDD患者中确定了年龄对抗抑郁治疗早期反应性与最终反应之间关联的影响。
