Bernstein H G, Bruszis S, Schmidt D, Wiederanders B, Dorn A
Institute of Anatomy, Medical Academy, Magdeburg.
J Hirnforsch. 1989;30(5):613-8.
The aspartic endopeptidase cathepsin D was immunolocalized in 21 human cadaver brains from patients with dementia and controls. Immunoreactive cathepsin D was found to be present in multiple neurons, neuritic plaques, some macroglial cells, and microvessels. It is suggested that the enzyme might be involved in certain posttranslational changes of cystoskeletal compounds that lead to the formation and/or further growth of neuritic plaques and neurofibrillary tangles.
天冬氨酸内肽酶组织蛋白酶D在21例痴呆患者和对照者的人脑尸检标本中进行了免疫定位。发现免疫反应性组织蛋白酶D存在于多个神经元、神经炎性斑块、一些大胶质细胞和微血管中。提示该酶可能参与了细胞骨架化合物的某些翻译后变化，这些变化导致神经炎性斑块和神经原纤维缠结的形成和/或进一步生长。
