Bernstein H G
Department of Psychiatry, School of Medicine, Otto von Guericke University Magdeburg, Germany.
Clin Neuropathol. 1997 Mar-Apr;16(2):69-71.
The neuroanatomical distribution of the proteinase kallikrein (EC. 3.4.21.35) in human brain was examined immunohistochemically by using antiserum against human tissue kallikrein. In normal nervous tissue only faint immunostaining of some neocortical and hippocampal neurons was observed. Glial cells were found to be immunonegative for kallikrein. In Alzheimer disease (AD) brains kallikrein-like immunoreactivity was associated, in some areas, with nerve cells and, especially in the neocortex, with numerous neuritic plaques. A possible function of the proteinase in AD-associated cascade of inflammatory response is supposed.
利用抗人组织激肽释放酶抗血清，通过免疫组织化学方法检测了蛋白酶激肽释放酶（EC. 3.4.21.35）在人脑内的神经解剖分布。在正常神经组织中，仅在一些新皮质和海马神经元中观察到微弱的免疫染色。发现神经胶质细胞对激肽释放酶呈免疫阴性。在阿尔茨海默病（AD）脑内，激肽释放酶样免疫反应性在某些区域与神经细胞相关，尤其在新皮质中，与大量神经炎性斑块相关。推测了该蛋白酶在AD相关炎症反应级联中的可能功能。
