侵袭性上皮性卵巢癌六个新易感基因座的鉴定。
Identification of six new susceptibility loci for invasive epithelial ovarian cancer.
作者信息
Kuchenbaecker Karoline B, Ramus Susan J, Tyrer Jonathan, Lee Andrew, Shen Howard C, Beesley Jonathan, Lawrenson Kate, McGuffog Lesley, Healey Sue, Lee Janet M, Spindler Tassja J, Lin Yvonne G, Pejovic Tanja, Bean Yukie, Li Qiyuan, Coetzee Simon, Hazelett Dennis, Miron Alexander, Southey Melissa, Terry Mary Beth, Goldgar David E, Buys Saundra S, Janavicius Ramunas, Dorfling Cecilia M, van Rensburg Elizabeth J, Neuhausen Susan L, Ding Yuan Chun, Hansen Thomas V O, Jønson Lars, Gerdes Anne-Marie, Ejlertsen Bent, Barrowdale Daniel, Dennis Joe, Benitez Javier, Osorio Ana, Garcia Maria Jose, Komenaka Ian, Weitzel Jeffrey N, Ganschow Pamela, Peterlongo Paolo, Bernard Loris, Viel Alessandra, Bonanni Bernardo, Peissel Bernard, Manoukian Siranoush, Radice Paolo, Papi Laura, Ottini Laura, Fostira Florentia, Konstantopoulou Irene, Garber Judy, Frost Debra, Perkins Jo, Platte Radka, Ellis Steve, Godwin Andrew K, Schmutzler Rita Katharina, Meindl Alfons, Engel Christoph, Sutter Christian, Sinilnikova Olga M, Damiola Francesca, Mazoyer Sylvie, Stoppa-Lyonnet Dominique, Claes Kathleen, De Leeneer Kim, Kirk Judy, Rodriguez Gustavo C, Piedmonte Marion, O'Malley David M, de la Hoya Miguel, Caldes Trinidad, Aittomäki Kristiina, Nevanlinna Heli, Collée J Margriet, Rookus Matti A, Oosterwijk Jan C, Tihomirova Laima, Tung Nadine, Hamann Ute, Isaccs Claudine, Tischkowitz Marc, Imyanitov Evgeny N, Caligo Maria A, Campbell Ian G, Hogervorst Frans B L, Olah Edith, Diez Orland, Blanco Ignacio, Brunet Joan, Lazaro Conxi, Pujana Miquel Angel, Jakubowska Anna, Gronwald Jacek, Lubinski Jan, Sukiennicki Grzegorz, Barkardottir Rosa B, Plante Marie, Simard Jacques, Soucy Penny, Montagna Marco, Tognazzo Silvia, Teixeira Manuel R, Pankratz Vernon S, Wang Xianshu, Lindor Noralane, Szabo Csilla I, Kauff Noah, Vijai Joseph, Aghajanian Carol A, Pfeiler Georg, Berger Andreas, Singer Christian F, Tea Muy-Kheng, Phelan Catherine M, Greene Mark H, Mai Phuong L, Rennert Gad, Mulligan Anna Marie, Tchatchou Sandrine, Andrulis Irene L, Glendon Gord, Toland Amanda Ewart, Jensen Uffe Birk, Kruse Torben A, Thomassen Mads, Bojesen Anders, Zidan Jamal, Friedman Eitan, Laitman Yael, Soller Maria, Liljegren Annelie, Arver Brita, Einbeigi Zakaria, Stenmark-Askmalm Marie, Olopade Olufunmilayo I, Nussbaum Robert L, Rebbeck Timothy R, Nathanson Katherine L, Domchek Susan M, Lu Karen H, Karlan Beth Y, Walsh Christine, Lester Jenny, Hein Alexander, Ekici Arif B, Beckmann Matthias W, Fasching Peter A, Lambrechts Diether, Van Nieuwenhuysen Els, Vergote Ignace, Lambrechts Sandrina, Dicks Ed, Doherty Jennifer A, Wicklund Kristine G, Rossing Mary Anne, Rudolph Anja, Chang-Claude Jenny, Wang-Gohrke Shan, Eilber Ursula, Moysich Kirsten B, Odunsi Kunle, Sucheston Lara, Lele Shashi, Wilkens Lynne R, Goodman Marc T, Thompson Pamela J, Shvetsov Yurii B, Runnebaum Ingo B, Dürst Matthias, Hillemanns Peter, Dörk Thilo, Antonenkova Natalia, Bogdanova Natalia, Leminen Arto, Pelttari Liisa M, Butzow Ralf, Modugno Francesmary, Kelley Joseph L, Edwards Robert P, Ness Roberta B, du Bois Andreas, Heitz Florian, Schwaab Ira, Harter Philipp, Matsuo Keitaro, Hosono Satoyo, Orsulic Sandra, Jensen Allan, Kjaer Susanne Kruger, Hogdall Estrid, Hasmad Hanis Nazihah, Azmi Mat Adenan Noor, Teo Soo-Hwang, Woo Yin-Ling, Fridley Brooke L, Goode Ellen L, Cunningham Julie M, Vierkant Robert A, Bruinsma Fiona, Giles Graham G, Liang Dong, Hildebrandt Michelle A T, Wu Xifeng, Levine Douglas A, Bisogna Maria, Berchuck Andrew, Iversen Edwin S, Schildkraut Joellen M, Concannon Patrick, Weber Rachel Palmieri, Cramer Daniel W, Terry Kathryn L, Poole Elizabeth M, Tworoger Shelley S, Bandera Elisa V, Orlow Irene, Olson Sara H, Krakstad Camilla, Salvesen Helga B, Tangen Ingvild L, Bjorge Line, van Altena Anne M, Aben Katja K H, Kiemeney Lambertus A, Massuger Leon F A G, Kellar Melissa, Brooks-Wilson Angela, Kelemen Linda E, Cook Linda S, Le Nhu D, Cybulski Cezary, Yang Hannah, Lissowska Jolanta, Brinton Louise A, Wentzensen Nicolas, Hogdall Claus, Lundvall Lene, Nedergaard Lotte, Baker Helen, Song Honglin, Eccles Diana, McNeish Ian, Paul James, Carty Karen, Siddiqui Nadeem, Glasspool Rosalind, Whittemore Alice S, Rothstein Joseph H, McGuire Valerie, Sieh Weiva, Ji Bu-Tian, Zheng Wei, Shu Xiao-Ou, Gao Yu-Tang, Rosen Barry, Risch Harvey A, McLaughlin John R, Narod Steven A, Monteiro Alvaro N, Chen Ann, Lin Hui-Yi, Permuth-Wey Jenny, Sellers Thomas A, Tsai Ya-Yu, Chen Zhihua, Ziogas Argyrios, Anton-Culver Hoda, Gentry-Maharaj Aleksandra, Menon Usha, Harrington Patricia, Lee Alice W, Wu Anna H, Pearce Celeste L, Coetzee Gerry, Pike Malcolm C, Dansonka-Mieszkowska Agnieszka, Timorek Agnieszka, Rzepecka Iwona K, Kupryjanczyk Jolanta, Freedman Matt, Noushmehr Houtan, Easton Douglas F, Offit Kenneth, Couch Fergus J, Gayther Simon, Pharoah Paul P, Antoniou Antonis C, Chenevix-Trench Georgia
机构信息
Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California, USA.
出版信息
Nat Genet. 2015 Feb;47(2):164-71. doi: 10.1038/ng.3185. Epub 2015 Jan 12.
Genome-wide association studies (GWAS) have identified 12 epithelial ovarian cancer (EOC) susceptibility alleles. The pattern of association at these loci is consistent in BRCA1 and BRCA2 mutation carriers who are at high risk of EOC. After imputation to 1000 Genomes Project data, we assessed associations of 11 million genetic variants with EOC risk from 15,437 cases unselected for family history and 30,845 controls and from 15,252 BRCA1 mutation carriers and 8,211 BRCA2 mutation carriers (3,096 with ovarian cancer), and we combined the results in a meta-analysis. This new study design yielded increased statistical power, leading to the discovery of six new EOC susceptibility loci. Variants at 1p36 (nearest gene, WNT4), 4q26 (SYNPO2), 9q34.2 (ABO) and 17q11.2 (ATAD5) were associated with EOC risk, and at 1p34.3 (RSPO1) and 6p22.1 (GPX6) variants were specifically associated with the serous EOC subtype, all with P < 5 × 10(-8). Incorporating these variants into risk assessment tools will improve clinical risk predictions for BRCA1 and BRCA2 mutation carriers.
全基因组关联研究（GWAS）已鉴定出12个上皮性卵巢癌（EOC）易感等位基因。在这些位点的关联模式在患EOC风险较高的BRCA1和BRCA2突变携带者中是一致的。在根据千人基因组计划数据进行归因后，我们评估了1100万个遗传变异与15437例未按家族史选择的病例和30845例对照的EOC风险之间的关联，以及与15252例BRCA1突变携带者和8211例BRCA2突变携带者（其中3096例患有卵巢癌）的EOC风险之间的关联，并将结果进行荟萃分析。这种新的研究设计提高了统计效力，从而发现了六个新的EOC易感位点。位于1p36（最接近的基因，WNT4）、4q26（SYNPO2）、9q34.2（ABO）和17q11.2（ATAD5）的变异与EOC风险相关，而位于1p34.3（RSPO1）和6p22.1（GPX6）的变异则与浆液性EOC亚型特异性相关，所有这些的P值均<5×10⁻⁸。将这些变异纳入风险评估工具将改善对BRCA1和BRCA2突变携带者的临床风险预测。
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