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改良的兔实验性烧伤模型

Improved experimental burn model on rabbits.

作者信息

Sobec Raluca L, Dobreanu C N, Magdas C N, Nagy A, Dinte Elena, Fodor Mm, Somcutean Ana, Tichil Ioana, Nastai M, Fodor L

机构信息

University of Medicine and Pharmacy Iuliu Haţ ieganu, Cluj-Napoca, Department of Plastic Surgery.

出版信息

Rev Med Chir Soc Med Nat Iasi. 2014 Oct-Dec;118(4):1047-53.

PMID:25581968
Abstract

OBJECTIVE

The goal of our study was to find an easy and suitable skin burn model for rabbits, to identify the temperature and contact time to reach a deep 2nd degree burn, and to find the best wound dressing fixation method.

MATERIAL AND METHODS

We used New Zealand male rabbits as experimental models. On a pilot study, with a copper device heated to temperatures between 43-48 Celsius degrees, the burn was inflicted using contact timesof 3, 4, 5, and 7 seconds. The burn depth was evaluated histological. Twenty-four rabbits were used to evaluate four dressing fixation methods: regular dressing with retention bandages; skin stapler; collars and body resin cast.

RESULTS

A 2nd degree deep burn was obtained at 43 degrees for 4 seconds. The retention elastic bandages were removed within hours and the skin staplers were removed with teeth leaving wounds on the skin. The collars were more successful but produced superficial neck lesions. The body resin casts were the most successful.

CONCLUSIONS

The best contention method was the bpdy resin cast.

摘要

目的

本研究的目的是为兔子找到一种简单合适的皮肤烧伤模型,确定达到深二度烧伤的温度和接触时间,并找到最佳的伤口敷料固定方法。

材料与方法

我们使用新西兰雄性兔子作为实验模型。在一项初步研究中,使用加热到43 - 48摄氏度的铜制装置,通过3、4、5和7秒的接触时间造成烧伤。通过组织学评估烧伤深度。使用24只兔子评估四种敷料固定方法:用保留绷带进行常规包扎;皮肤吻合器;项圈和身体树脂石膏。

结果

在43度接触4秒时获得深二度烧伤。保留弹性绷带在数小时内就脱落了,皮肤吻合器用牙齿取下时在皮肤上留下伤口。项圈更成功,但会造成颈部浅表损伤。身体树脂石膏是最成功的。

结论

最佳的固定方法是身体树脂石膏。

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