Royal Alexandra Hospital, Paisley, UK.
Royal Alexandra Hospital, Paisley, UK.
Resuscitation. 2015 Apr;89:31-5. doi: 10.1016/j.resuscitation.2014.12.029. Epub 2015 Jan 9.
Early intervention and response to deranged physiological parameters in the critically ill patient improves outcomes. A National Early Warning Score (NEWS) based on physiological observations has been developed for use throughout the National Health Service (NHS) in the UK. Although a good predictor of mortality and deterioration in inpatients, its performance in the prehospital setting is largely untested. This study aimed to assess the validity of the NEWS in unselected prehospital patients.
All clinical observations taken by emergency ambulance crews transporting patients to a single hospital were collated along with information relating to hospital outcome over a two month period. The performance of the NEWS in identifying the endpoints of 48h and 30 day mortality, intensive care unit (ICU) admission, and a combined endpoint of 48h mortality or ICU admission was analysed.
1684 patients were analysed. All three of the primary endpoints and the combined endpoint were associated with higher NEWS scores (p<0.01 for each). The medium-risk NEWS group was associated with a statistically significant increase in ICU admission (RR=2.466, 95% CI 1.0-6.09), but not in-hospital mortality relative to the low risk group. The high risk NEWS group had significant increases in 48h mortality (RR 35.32 [10.08-123.7]), 30 day mortality (RR 6.7 [3.79-11.88]), and ICU admission (5.43 [2.29-12.89]). Similar results were noted when trauma and non-trauma patients were analysed separately.
Elevated NEWS among unselected prehospital patients is associated with a higher incidence of adverse outcomes. Calculation of prehospital NEWS may facilitate earlier recognition of deteriorating patients, early involvement of senior Emergency Department staff and appropriate critical care.
对危重病患者异常生理参数的早期干预和响应可改善预后。一种基于生理观察的国家早期预警评分(NEWS)已在英国国民保健制度(NHS)中开发并应用。尽管它是住院患者死亡率和恶化的良好预测指标,但在院前环境中的性能在很大程度上未经测试。本研究旨在评估 NEWS 在未经选择的院前患者中的有效性。
在两个月的时间内,收集了运送至一家医院的急救车工作人员记录的所有临床观察结果,以及与医院结局相关的信息。分析了 NEWS 在识别 48 小时和 30 天死亡率、重症监护病房(ICU)入院以及 48 小时死亡率或 ICU 入院的联合终点方面的性能。
共分析了 1684 名患者。所有三个主要终点和联合终点均与更高的 NEWS 评分相关(p<0.01)。与低危组相比,中危 NEWS 组 ICU 入院率显著增加(RR=2.466,95%CI 1.0-6.09),但院内死亡率无统计学差异。高危 NEWS 组 48 小时死亡率(RR 35.32 [10.08-123.7])、30 天死亡率(RR 6.7 [3.79-11.88])和 ICU 入院率(RR 5.43 [2.29-12.89])显著增加。当分别分析创伤和非创伤患者时,也得到了类似的结果。
在未经选择的院前患者中,NEWS 升高与不良结局的发生率增加相关。计算院前 NEWS 可能有助于更早识别病情恶化的患者,更早地让急诊部高级医务人员参与,并提供适当的重症监护。