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[社区中85岁以上贫血患者的概况与预后。奥克塔baix研究]

[Profile and prognosis of patients over 85 years old with anemia living in the community. Octabaix Study].

作者信息

Contreras M Del Mar, Formiga Francesc, Ferrer Assumpta, Chivite David, Padrós Glòria, Montero Abelardo

机构信息

Servicio de Medicina Interna, Hospital Universitario de La Princesa, Madrid, España.

Unidad de Geriatría, Servicio Medicina Interna, Hospital Universitari de Bellvitge, L'Hospitalet de Llobregat, Barcelona, España; Bellvitge Biomedical Research Institute, IDIBELL, L'Hospitalet de Llobregat, Barcelona, España.

出版信息

Rev Esp Geriatr Gerontol. 2015 Sep-Oct;50(5):211-5. doi: 10.1016/j.regg.2014.11.004. Epub 2015 Jan 9.

Abstract

OBJECTIVES

To analyze the prevalence of anemia in a sample of patients over 85 years old. To explore possible differentiating features in the groups of people with and without anemia, and to evaluate the relationship of anemia with mortality after a follow-up of 3 years.

MATERIAL AND METHODS

An observational multicenter study was conducted on a cohort of people born in 1924 and who lived in the community. Socio-demographic variables, comorbidity, functionality, cognitive status, social risk, perceived quality of life, nutritional status, drug consumption and laboratory parameters were collected. Multivariate logistic regression analysis was performed.

RESULTS

A total of 328 inhabitants were included, of whom 61.6% were women. The prevalence of anemia was 24%. Statistically significant differences in the Charlson index were found, showing higher values in anemic patients (P=0001) and in the Barthel index (BI) and in the Lawton index (LI), with lower levels in anemic patients (P=002 for both). Patients with anemia had a poorer perception of their quality of life (P=015). The presence of anemia was associated with more dependence according the BI values (OR 0.985; 95% CI: 0973-0997) and with higher comorbidity according the Charlson index (OR 1.314; 95% CI: 1124-1536). Mortality was higher in the group of patients with anemia, reaching statistically significant differences in the third year P=005).

CONCLUSIONS

In our cohort anemia is a fairly prevalent feature in the population over 85 years old, and is associated with higher mortality at three years of follow up. Patients with anemia had worse physical functioning and greater comorbidity.

摘要

目的

分析85岁以上患者样本中贫血的患病率。探讨贫血患者与非贫血患者群体中可能存在的差异特征,并评估贫血与3年随访后死亡率之间的关系。

材料与方法

对一组出生于1924年且居住在社区的人群进行了一项多中心观察性研究。收集了社会人口统计学变量、合并症、功能状态、认知状态、社会风险、生活质量感知、营养状况、药物消费和实验室参数。进行了多变量逻辑回归分析。

结果

共纳入328名居民,其中61.6%为女性。贫血患病率为24%。在查尔森指数上发现了统计学上的显著差异,贫血患者的值更高(P = 0.001),在巴氏指数(BI)和洛顿指数(LI)上,贫血患者的水平较低(两者P均 = 0.002)。贫血患者对生活质量的感知较差(P = 0.015)。根据BI值,贫血的存在与更多的依赖相关(OR 0.985;95% CI:0.973 - 0.997),根据查尔森指数,与更高的合并症相关(OR 1.314;95% CI:1.124 - 1.536)。贫血患者组的死亡率更高,在第三年达到统计学显著差异(P = 0.005)。

结论

在我们的队列中,贫血在85岁以上人群中是一个相当普遍的特征,并且与3年随访时较高的死亡率相关。贫血患者的身体功能较差且合并症较多。

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