老年男性活动性幽门螺杆菌感染与贫血的关系。
Association of active Helicobacter pylori infection and anemia in elderly males.
机构信息
Department of Gastroenterology, The Second Medical Center, Chinese PLA General Hospital and National Clinical Research Center for Geriatric Diseases, Beijing, 100853, People's Republic of China.
Department of Epidemiology, Institute of Geriatrics, The Second Medical Center, Chinese PLA General Hospital and National Clinical Research Center for Geriatric Diseases, Beijing, 100853, People's Republic of China.
出版信息
BMC Infect Dis. 2019 Mar 5;19(1):228. doi: 10.1186/s12879-019-3849-y.
BACKGROUND
The prevalence of Helicobacter pylori (H. pylori) infection increases with age. However, the relationship between H. pylori infection and anemia in the elderly population remains to be identified. The aim of this study is to explore whether H. pylori infection is associated with anemia in a male elderly cohort.
METHODS
A cross-sectional study was designed using data collected from asymptomatic male senior citizens (≥ 65 years old) who received an assessment of their health status at the General Hospital of Chinese PLA from January 2015 to December 2015. H. pylori infection was confirmed by the C-urea breath test. Blood samples from the participants were taken to assay for hemoglobin and other erythroid-related indices - serum iron, ferritin, and C-reactive protein (CRP). Anemia was defined as hemoglobin values lower than 120.0 g/L. Charlson Comorbidity Index (CCI) was applied to establish baseline comorbidities.
RESULTS
Data from 646 subjects were analyzed. The mean age of the study cohort was 79.4 ± 8.9 years. The overall prevalence of H. pylori infection was 35.3%. The prevalence of anemia in the H. pylori positive group was higher than that in the negative group (5.3% vs. 2.2%, P = .033). Among the patients who had higher CCI scores (> 2), the prevalence of anemia in the H. pylori positive and negative groups were 10.3 and 1.4%, respectively (P = .009). Compared to the H. pylori negative group, the odds ratio for anemia of the H. pylori positive group was 2.53 (P = .033). No correlation between H. pylori infection and serum iron and ferritin levels was found. The mean corpuscular volume of the H. pylori positive and negative group was 91.17 ± 3.94 fl and 91.17 ± 4.09 fl (mean ± SD), respectively (P = .986). The CRP level in the H. pylori positive group was higher than that in the H. pylori negative group (Median: 0.17 mg/dL vs. 0.10 mg/dL, P < .001).
CONCLUSION
H. pylori infection seems to be associated with normocytic and normochromic anemia in elderly males, especially in those with more comorbidities. Further clinical studies are needed to verify the association.
背景
幽门螺杆菌（H. pylori）感染的流行率随年龄增长而增加。然而，老年人中 H. pylori 感染与贫血之间的关系仍有待确定。本研究旨在探讨男性老年人群中 H. pylori 感染是否与贫血有关。
方法
采用横断面研究设计，收集 2015 年 1 月至 12 月在中国人民解放军总医院接受健康评估的无症状老年男性（≥65 岁）的数据。通过 C-尿素呼气试验确认 H. pylori 感染。采集参与者的血样检测血红蛋白和其他红细胞相关指标-血清铁、铁蛋白和 C 反应蛋白（CRP）。贫血定义为血红蛋白值低于 120.0 g/L。应用 Charlson 合并症指数（CCI）确定基线合并症。
结果
共分析了 646 名受试者的数据。研究队列的平均年龄为 79.4 ± 8.9 岁。H. pylori 感染的总体流行率为 35.3%。H. pylori 阳性组贫血的发生率高于阴性组（5.3%比 2.2%，P =.033）。在 CCI 评分较高（>2）的患者中，H. pylori 阳性和阴性组贫血的发生率分别为 10.3%和 1.4%（P =.009）。与 H. pylori 阴性组相比，H. pylori 阳性组贫血的优势比为 2.53（P =.033）。未发现 H. pylori 感染与血清铁和铁蛋白水平之间存在相关性。H. pylori 阳性和阴性组的平均红细胞体积分别为 91.17 ± 3.94 fl 和 91.17 ± 4.09 fl（均值 ± 标准差）（P =.986）。H. pylori 阳性组的 CRP 水平高于 H. pylori 阴性组（中位数：0.17 mg/dL 比 0.10 mg/dL，P <.001）。
结论
H. pylori 感染似乎与老年男性的正细胞正色素性贫血有关，尤其是在合并症较多的患者中。需要进一步的临床研究来验证这种关联。
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