一种合成正交保护的呋喃基和噻吩基氨基酸的直接方法。

A direct method for the synthesis of orthogonally protected furyl- and thienyl- amino acids.

作者信息

Hudson Alex S, Caron Laurent, Colgin Neil, Cobb Steven L

机构信息

Department of Chemistry, Durham University, South Road, Durham, DH1 3LE, UK.

出版信息

Amino Acids. 2015 Apr;47(4):779-85. doi: 10.1007/s00726-014-1908-7. Epub 2015 Jan 13.

DOI:10.1007/s00726-014-1908-7

PMID:25583604

Abstract

The synthesis of unnatural amino acids plays a key part in expanding the potential application of peptide-based drugs and in the total synthesis of peptide natural products. Herein, we report a direct method for the synthesis of orthogonally protected 5-membered heteroaromatic amino acids.

摘要

非天然氨基酸的合成在拓展基于肽的药物的潜在应用以及肽类天然产物的全合成中起着关键作用。在此，我们报道一种合成正交保护的五元杂环芳香族氨基酸的直接方法。