Arowojolu A O, Otolorin E O, Ladipo O A
Department of Obstetrics and Gynaecology, University College Hospital, Ibadan, Nigeria.
Afr J Med Med Sci. 1989 Dec;18(4):295-9.
The systemic absorption of copper incorporated into multiload intra-uterine contraceptive devices (IUDs), as indicated by serum copper levels in users of such devices, was assessed in a prospective longitudinal study. One hundred and ten healthy Nigerian women using either multiload copper 250 (MLCU 250) or multiload copper 375 (MLCU 375) IUDs participated in the study. Their serum copper levels were estimated serially during 12 months of continuous use of the devices. The mean (+/- s.e.m.) pre-insertion serum copper levels of our subjects using MLCU 250 (17.0 +/- 3 mumol/l) and MLCU 375 (16.7 +/- 0.5 mumol/l) were found to be lower than those reported in Americans (22.2 mumol/l) and in Germans (20.2 mumol/l), although similar to levels in Indians (17.0 mumol/l). There was no significant difference in the mean serum copper levels estimated before and after 1 month of continuous use of the device. Serial estimations of the serum copper levels in users showed that there was no alteration in these levels after a period of 12 months of continuous IUD use. We therefore conclude that the copper incorporated into multiload IUDs appears not to influence the concentration of serum copper of users.
在一项前瞻性纵向研究中，通过使用此类宫内节育器（IUD）的使用者的血清铜水平，评估了含铜多负载宫内节育器中铜的全身吸收情况。110名使用多负载铜250（MLCU 250）或多负载铜375（MLCU 375）宫内节育器的健康尼日利亚女性参与了该研究。在持续使用这些装置的12个月期间，对她们的血清铜水平进行了连续测定。我们发现，使用MLCU 250（17.0 +/- 3 μmol/l）和MLCU 375（16.7 +/- 0.5 μmol/l）的受试者插入前的平均（+/-标准误）血清铜水平低于美国人（22.2 μmol/l）和德国人（20.2 μmol/l）报告的水平，不过与印度人（17.0 μmol/l）的水平相似。在持续使用该装置1个月前后测定的平均血清铜水平没有显著差异。对使用者血清铜水平的连续测定表明，在持续使用宫内节育器12个月后，这些水平没有变化。因此，我们得出结论，含铜多负载宫内节育器中的铜似乎不会影响使用者的血清铜浓度。
