肥胖症和普拉德-威利综合征中的自主神经系统功能障碍：当前证据及对未来肥胖症治疗的启示
Autonomic nervous system dysfunction in obesity and Prader-Willi syndrome: current evidence and implications for future obesity therapies.
作者信息
Haqq A M, DeLorey D S, Sharma A M, Freemark M, Kreier F, Mackenzie M L, Richer L P
机构信息
Department of Pediatrics, University of Alberta, Edmonton, AB, CanadaFaculty of Physical Education and Recreation, University of Alberta, Edmonton, AB, CanadaDepartment of Medicine, University of Alberta, Edmonton, AB, CanadaDepartment of Pediatrics, Duke University Medical Center, Durham, NC, USADepartment of Pediatrics, University of Amsterdam, Amsterdam, the Netherlands.
出版信息
Clin Obes. 2011 Aug;1(4-6):175-83. doi: 10.1111/j.1758-8111.2012.00032.x.
The autonomic nervous system (ANS) controls essential functions like breathing, heart rate, digestion, body temperature and hormone levels. Evidence suggests that ANS dysfunction is associated with adult and childhood obesity and plays a role in the distribution of total body fat and the development of obesity-related complications in humans. This review summarizes our current understanding of ANS involvement in the pathogenesis of obesity and Prader-Willi syndrome. Available evidence of ANS dysfunction in the control of energy balance is limited and, in some cases, contradictory. Further investigation in this area is warranted in order to better understand the important contributions of the ANS to regulation of body fat, development of obesity and its comorbidities. Results from these studies will guide the development of novel obesity therapeutics targeting specific ANS dysfunction.
自主神经系统（ANS）控制着呼吸、心率、消化、体温和激素水平等基本功能。有证据表明，自主神经系统功能障碍与成人和儿童肥胖有关，并在人体全身脂肪分布以及肥胖相关并发症的发生发展中起作用。本综述总结了我们目前对自主神经系统参与肥胖症和普拉德-威利综合征发病机制的理解。自主神经系统功能障碍在能量平衡控制方面的现有证据有限，且在某些情况下相互矛盾。有必要对该领域进行进一步研究，以便更好地了解自主神经系统对身体脂肪调节、肥胖症及其合并症发展的重要作用。这些研究结果将指导针对特定自主神经系统功能障碍的新型肥胖症治疗方法的开发。
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