Zhou Tian-Biao, Jiang Zong-Pei
Department of Nephrology, The Sixth Affiliated Hospital, Sun Yat-Sen University , Guangzhou , China.
Ren Fail. 2015 Apr;37(3):459-61. doi: 10.3109/0886022X.2014.1001711. Epub 2015 Jan 14.
The rate of hepatitis B virus (HBV) infection is high in the Chinese population, and the implications of HBV infection are widely recognized, and membranous nephropathy is the most common renal lesion to be associated with HBV infection. Minimal change disease (MCD) is one of the most important histopathological characteristics in patients with nephrotic syndrome. There is no any study to report that HBV infection is associated with the etiology of MCD. Herein, we report four MCD patients with HBV infection and speculate that there is an association of HBV infection with the pathological type of MCD. In this study, we also reported the treatment schedule for these four MCD patients, and found that the anti-virus alone and combination of anti-virus with immunosuppressive agent could obtain a benefit for MCD patients with HBV infection. However, a well-designed study should be performed to confirm this association.
中国人群中乙肝病毒（HBV）感染率较高，HBV感染的影响已得到广泛认可，膜性肾病是与HBV感染相关的最常见肾脏病变。微小病变肾病（MCD）是肾病综合征患者最重要的组织病理学特征之一。尚无研究报道HBV感染与MCD的病因有关。在此，我们报告了4例合并HBV感染的MCD患者，并推测HBV感染与MCD的病理类型有关。在本研究中，我们还报告了这4例MCD患者的治疗方案，发现单独抗病毒治疗以及抗病毒与免疫抑制剂联合治疗对合并HBV感染的MCD患者有益。然而，需要进行精心设计的研究来证实这种关联。
