Connolly Sara B, Prager Joshua P, Harden R Norman
Center for Pain Studies, Rehabilitation Institute of Chicago, Chicago, Illinois, USA.
Center for the Rehabilitation Pain Syndromes (CRPS) at UCLA Medical Plaza, Los Angeles, California, USA.
Pain Med. 2015 May;16(5):943-69. doi: 10.1111/pme.12675. Epub 2015 Jan 13.
This systematic review aims to examine the available literature and to synthesize published data concerning the treatment of Complex Regional Pain Syndrome (CRPS) with ketamine.
The search was conducted utilizing the databases Medline, Embase and the Cochrane Central Registry of Controlled Trials. All relevant articles were systematically reviewed.
The search yielded 262 articles, 45 of which met the inclusion/exclusion criteria. Of those included, 6 were reviews, 5 were randomized placebo-controlled trials, 13 were observational studies, and 21 were case reports.
There is no high quality evidence available evaluating the efficacy of ketamine for CRPS and all manuscripts examined in this review were of moderate to low quality. Therefore, we conclude there is currently only weak evidence supporting the efficacy of ketamine for CRPS, yet there is clearly a rationale for definitive study.
本系统评价旨在研究现有文献，并综合已发表的有关氯胺酮治疗复杂性区域疼痛综合征（CRPS）的数据。
利用Medline、Embase数据库以及Cochrane对照试验中央注册库进行检索。对所有相关文章进行系统评价。
检索到262篇文章，其中45篇符合纳入/排除标准。纳入的文章中，6篇为综述，5篇为随机安慰剂对照试验，13篇为观察性研究，21篇为病例报告。
目前尚无高质量证据评估氯胺酮治疗CRPS的疗效，本综述中审查的所有手稿质量均为中等或低等。因此，我们得出结论：目前仅有微弱证据支持氯胺酮治疗CRPS的疗效，但显然有理由进行确定性研究。
