Department of Anesthesiology, Critical Care and Pain Medicine, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Harvard Medical School, Boston, MA, USA.
Curr Pain Headache Rep. 2018 Feb 5;22(2):10. doi: 10.1007/s11916-018-0667-7.
Complex regional pain syndrome (CRPS) refers to a chronic pain condition that is characterized by progressively worsening spontaneous regional pain without dermatomal distribution. The symptomatology includes pain out of proportion in time and severity to the inciting event. The purpose of this review is to present the most current information concerning epidemiology, diagnosis, pathophysiology, and therapy for CRPS.
In recent years, discovery of pathophysiologic mechanisms of CRPS has led to significant strides in the understanding of the disease process. Continued elucidation of the underlying pathophysiological mechanisms will allow for the development of more targeted and effective evidence-based therapy protocols. Further large clinical trials are needed to investigate mechanisms and treatment of the disorder.
复杂性区域疼痛综合征（CRPS）是一种慢性疼痛疾病，其特征为自发性区域性疼痛逐渐恶化，且无皮节分布。其症状包括与诱发事件不成比例的时间和严重程度的疼痛。本文综述的目的是介绍 CRPS 的流行病学、诊断、病理生理学和治疗的最新信息。
近年来，CRPS 病理生理机制的发现使得人们对疾病过程的认识有了重大进展。对潜在病理生理机制的进一步阐明将有助于制定更有针对性和更有效的循证治疗方案。需要进一步的大型临床试验来研究该疾病的发病机制和治疗方法。
