Dungan Kathleen, Binkley Philip, Osei Kwame
Division of Endocrinology, Diabetes and Metabolism, The Ohio State University, 5th Floor McCampbell Hall, 1581 Dodd Drive, Columbus, OH, 43210-1296, USA,
Inflammation. 2015;38(3):1357-63. doi: 10.1007/s10753-014-0107-8.
GlycA is a nuclear magnetic resonance-derived signal that originates from oligosaccharide chains of acute phase proteins. The objective of this study is to characterize GlycA levels in hospitalized non-critically ill patients with type 2 diabetes. This study evaluated traditional and novel (GlycA) inflammatory markers among 121 patients who were stratified by admission diagnoses: congestive heart failure (CHF), cardiac non-CHF (CARD), infection (INF), and other (OTH). HbA1c was similar across groups (8.0-9.2%, p=0.20). Inflammatory markers were elevated but varied significantly across disease categories, with the highest values of interleukin-6 (IL-6), c-reactive protein (CRP), and GlycA in the INF group and the highest tumor necrosis factor-α and intracellular adhesion molecule-1 levels in CHF group. GlycA was associated with higher IL-6 and CRP, lower hemoglobin, and lower glomerular filtration rate. GlycA and other inflammatory markers were not significantly associated with admission glucose or HbA1c. Among hospitalized non-critically ill patients with type 2 diabetes, GlycA was highest in INF patients and was associated with IL-6 and CRP. None of the markers were significant predictors of glucose control.
糖化白蛋白（GlycA）是一种源自急性期蛋白寡糖链的核磁共振衍生信号。本研究的目的是对住院的非危重型2型糖尿病患者的GlycA水平进行特征描述。本研究评估了121例患者的传统和新型（GlycA）炎症标志物，这些患者按入院诊断分层为：充血性心力衰竭（CHF）、非CHF心脏疾病（CARD）、感染（INF）和其他（OTH）。各组间糖化血红蛋白（HbA1c）相似（8.0 - 9.2%，p = 0.20）。炎症标志物升高，但在不同疾病类别中差异显著，INF组白细胞介素-6（IL-6）、C反应蛋白（CRP）和GlycA值最高，CHF组肿瘤坏死因子-α和细胞间黏附分子-1水平最高。GlycA与较高的IL-6和CRP、较低的血红蛋白以及较低的肾小球滤过率相关。GlycA和其他炎症标志物与入院时血糖或HbA1c无显著关联。在住院的非危重型2型糖尿病患者中，INF患者的GlycA最高，且与IL-6和CRP相关。这些标志物均不是血糖控制的显著预测指标。
