Dullaart Robin P F, Gruppen Eke G, Connelly Margery A, Otvos James D, Lefrandt Joop D
Department of Endocrinology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Department of Endocrinology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands; Department of Nephrology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Clin Biochem. 2015 Aug;48(12):811-4. doi: 10.1016/j.clinbiochem.2015.05.001. Epub 2015 May 11.
Plasma GlycA is a recently developed biomarker whose nuclear magnetic resonance signal originates from glycosylated acute-phase proteins. The aim of our study was to determine potential relationships between GlycA and adiposity, insulin resistance (HOMA(ir)), high sensitive C-reactive protein (hs-CRP), leptin, adiponectin, and the leptin/adiponectin ratio, and to test whether GlycA is elevated in subjects with impaired fasting glucose (IFG) and type 2 diabetes mellitus (T2DM).
Plasma GlycA, hs-CRP, leptin, adiponectin, the leptin/adiponectin ratio, and insulin resistance (HOMA(ir)) were measured in 103 fasting subjects (30 with normal fasting glucose, 25 with IFG and 48 with T2DM).
In all subjects combined, plasma GlycA was correlated positively with body mass index (BMI), HOMA(ir), hs-CRP, leptin and the leptin/adiponectin ratio, and inversely with adiponectin (p < 0.05 to p < 0.001). GlycA did not significantly vary according to glucose tolerance category (p = 0.060). GlycA was related positively to the leptin/adiponectin ratio (p = 0.049), independent of BMI (p = 0.056) and HOMA(ir) (p = 0.50).
High plasma GlycA reflects a pro-inflammatory state. Adipose tissue-associated inflammatory processes could contribute to increased circulating levels of glycosylated acute-phase proteins.
血浆糖化白蛋白（GlycA）是一种最近开发的生物标志物，其核磁共振信号源自糖基化急性期蛋白。我们研究的目的是确定GlycA与肥胖、胰岛素抵抗（HOMA-IR）、高敏C反应蛋白（hs-CRP）、瘦素、脂联素以及瘦素/脂联素比值之间的潜在关系，并测试空腹血糖受损（IFG）和2型糖尿病（T2DM）患者的GlycA水平是否升高。
对103名空腹受试者（30名空腹血糖正常、25名IFG和48名T2DM患者）测量血浆GlycA、hs-CRP、瘦素、脂联素、瘦素/脂联素比值和胰岛素抵抗（HOMA-IR）。
在所有受试者中，血浆GlycA与体重指数（BMI）、HOMA-IR、hs-CRP、瘦素和瘦素/脂联素比值呈正相关，与脂联素呈负相关（p<0.05至p<0.001）。GlycA在不同糖耐量类别之间无显著差异（p=0.060）。GlycA与瘦素/脂联素比值呈正相关（p=0.049），独立于BMI（p=0.056）和HOMA-IR（p=0.50）。
高血浆GlycA反映了一种促炎状态。脂肪组织相关的炎症过程可能导致糖基化急性期蛋白循环水平升高。
