Kelsey J E, Carlezon W A, Falls W A
Department of Psychology, Bates College, Lewiston, Maine 04240.
Behav Neurosci. 1989 Dec;103(6):1327-34. doi: 10.1037//0735-7044.103.6.1327.
Bilateral electrolytic lesions of the nucleus accumbens in rats eliminated the capacity of 10 mg/kg morphine to produce a conditioned place preference (Experiment 1). However, these lesions did not alter the capacity to establish context-specific tolerance to the analgesic effects of 5 mg/kg of morphine (Experiment 2). This latter finding indicates that rats with nucleus accumbens lesions are not impaired in associating the effects of morphine with a particular location. Thus, the failure of morphine to produce a conditioned place preference in these lesioned rats probably cannot be attributed to an inability to associate the effects of morphine with a particular chamber, i.e., the initially nonpreferred chamber. Rather, morphine may fail to establish a conditioned place preference in these rats because nucleus accumbens lesions disrupt a pathway that is critical in mediating the rewarding effects of opiates.
大鼠伏隔核的双侧电解损伤消除了10毫克/千克吗啡产生条件性位置偏好的能力（实验1）。然而，这些损伤并未改变建立对5毫克/千克吗啡镇痛作用的情境特异性耐受性的能力（实验2）。后一发现表明，伏隔核损伤的大鼠在将吗啡的作用与特定位置联系起来方面没有受损。因此，在这些损伤大鼠中吗啡未能产生条件性位置偏好，可能不能归因于无法将吗啡的作用与特定腔室（即最初不偏好的腔室）联系起来。相反，吗啡可能无法在这些大鼠中建立条件性位置偏好，因为伏隔核损伤破坏了一条在介导阿片类药物奖赏作用中至关重要的通路。
