Weber Christian, Döring Yvonne, Noels Heidi
Prof. Dr. med. Christian Weber, Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians-University Munich, Pettenkoferstraße 9, 80336 Munich, Germany, E-mail:
Hamostaseologie. 2016 May 10;36(2):97-102. doi: 10.5482/HAMO-14-10-0054. Epub 2015 Jan 14.
The chemokine CXCL12 and its receptor CXCR4 form an important axis contributing to cellular functions in homeostasis and disease. In addition, the atypical CXCL12 receptor CXCR7 may shape the availability and function of CXCL12. Further to their role through progenitor cell mobilization, CXCL12 and CXCR4 may affect native atherogenesis by modifying atherosclerosis-relevant cellular functions. This short review intends to provide a concise summary of current knowledge with regards to cell-specific functions of CXCL12 and its receptors CXCR4 and CXCR7 with potential implications for the initiation and progression of atherosclerosis.
趋化因子CXCL12及其受体CXCR4构成了一个重要轴，对体内平衡和疾病中的细胞功能发挥作用。此外，非典型趋化因子CXCL12受体CXCR7可能会影响CXCL12的可用性和功能。除了通过祖细胞动员发挥作用外，CXCL12和CXCR4还可能通过改变与动脉粥样硬化相关的细胞功能来影响原发性动脉粥样硬化的发生。本简短综述旨在简要总结关于CXCL12及其受体CXCR4和CXCR7的细胞特异性功能的当前知识，及其对动脉粥样硬化起始和进展的潜在影响。
