Safarnavadeh Tahereh, Rastegarpanah Mansoor
Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
Department of Clinical Pharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran. ; Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
Iran J Reprod Med. 2011 Spring;9(2):61-70.
The use of antioxidants in the treatment of infertility has been suggested and recent studies have indicated that oral administration of Satureja Khuzestanica essential oil (SKEO) to rats induces significant antioxidative effects.
This systematic review was conducted to evaluate the effectiveness of antioxidants in infertility and also to assess the effectiveness of Satureja Khuzestanica in infertility management.
Pubmed, Scopus, and Cochrane Library were searched for relevant trials published from respective database inception dates to August 2010. Study selection, and data extraction were performed by authors.
Fifteen trials on evaluation of antioxidants in infertility and seven studies on the effectiveness of Satureja Khuzestanica were identified. Only 4 of the 15 trials were with application of allocation concealment and three studies were done in in-vitro environment. Despite the methodological and clinical heterogeneity of the trials, 14 of the 15 (93.33%) trials showed an improvement in either sperm quality or pregnancy rate after antioxidant therapy. The human and animal studies of Satureja Khuzestanica showed a significant antioxidative potential of the plant and its effectiveness for infertility improvement.
The use of oral antioxidants in infertility could improve sperm quality and pregnancy rates. Improved fertility observed by SKEO in rats might be due to its antioxidative effect. Further studies and clinical trials in humans are necessary to evaluate SKEO effectiveness in fertility disturbances.
已有研究建议使用抗氧化剂治疗不孕症，近期研究表明，给大鼠口服胡齐斯坦鼠尾草精油（SKEO）可产生显著的抗氧化作用。
进行本系统评价以评估抗氧化剂治疗不孕症的有效性，并评估胡齐斯坦鼠尾草在不孕症治疗中的有效性。
检索了PubMed、Scopus和Cochrane图书馆，查找从各数据库建库至2010年8月发表的相关试验。由作者进行研究选择和数据提取。
共确定了15项评估抗氧化剂治疗不孕症的试验以及7项关于胡齐斯坦鼠尾草有效性的研究。15项试验中只有4项采用了分配隐藏，3项研究在体外环境中进行。尽管试验在方法学和临床方面存在异质性，但15项试验中的14项（93.33%）显示抗氧化剂治疗后精子质量或妊娠率有所改善。关于胡齐斯坦鼠尾草的人体和动物研究表明，该植物具有显著的抗氧化潜力，且对改善不孕症有效。
口服抗氧化剂治疗不孕症可改善精子质量和提高妊娠率。SKEO在大鼠中观察到的生育力提高可能归因于其抗氧化作用。有必要在人体中开展进一步研究和临床试验，以评估SKEO对生育障碍的有效性。
