Vanĕcek J, Vollrath L
Department of Anatomy, Johannes Gutenberg University, Mainz F.R.G.
Brain Res. 1989 Dec 25;505(1):157-9. doi: 10.1016/0006-8993(89)90129-7.
Subnanomolar concentrations of melatonin inhibit cyclic AMP and cyclic GMP accumulation in neonatal rat anterior pituitary stimulated in vitro with luteinizing-hormone releasing-hormone. Melatonin also inhibited forskolin-stimulated cyclic AMP accumulation in pars tuberalis. Inhibition of cyclic AMP accumulation is specific for melatonin, since its analogs N-acetylserotonin and 5-methoxytryptamine are 1000 times less potent. Cyclic nucleotides may thus serve as second messengers transducing the effect of melatonin on cellular level.
亚纳摩尔浓度的褪黑素可抑制体外培养的新生大鼠垂体前叶中由促黄体生成素释放激素刺激引起的环磷酸腺苷（cAMP）和环磷酸鸟苷（cGMP）的积累。褪黑素还可抑制结节部中由福斯高林刺激引起的cAMP积累。cAMP积累的抑制作用对褪黑素具有特异性，因为其类似物N - 乙酰血清素和5 - 甲氧基色胺的效力要低1000倍。因此，环核苷酸可能作为第二信使在细胞水平上传递褪黑素的作用。
