CCNU-uOttawa Joint Research Centre, Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University , 152 Luoyu Road, Wuhan 430079, P. R. China.
J Am Chem Soc. 2015 Feb 25;137(7):2763-8. doi: 10.1021/jacs.5b00085. Epub 2015 Feb 13.
An asymmetric hydrogenation reaction of benzoxazinones has been accomplished via a relay iron/chiral Brønsted acid catalysis. This approach provides a variety of chiral dihydrobenzoxazinones in good to high yields (75-96%) and enantioselectivities (up to 98:2 er). It is noteworthy that challenging 3-alkyl-substituted substrates underwent highly enantioselective reduction. A key to success is the utilization of a nonchiral phosphine ligand to reduce disadvantageous background reactions through tuning the catalytic activity of Fe3(CO)12.
通过接力铁/手性 Brønsted 酸催化，实现了苯并恶嗪酮的不对称氢化反应。该方法以良好到优秀的收率（75-96%）和对映选择性（高达 98:2 er）提供了各种手性二氢苯并恶嗪酮。值得注意的是，具有挑战性的 3-烷基取代底物经历了高度对映选择性还原。成功的关键是利用非手性膦配体通过调节 Fe3(CO)12 的催化活性来减少不利的背景反应。
