可见光诱导/布朗斯特酸催化接力的四氢喹啉的对映选择性合成。
Visible-Light Induction/Brønsted Acid Catalysis in Relay for the Enantioselective Synthesis of Tetrahydroquinolines.
机构信息
College of Chemistry and Chemical Engineering , Hunan University , Changsha 410082 , People's Republic of China.
出版信息
Org Lett. 2019 Jun 7;21(11):4173-4176. doi: 10.1021/acs.orglett.9b01354. Epub 2019 May 24.
PMID:31124682
Abstract
An efficient method merging Brønsted acid catalysis with visible-light induction for the highly enantioselective synthesis of tetrahydroquinolines has been developed. This mild process directly transforms 2-aminoenones into 2-substituted tetrahydroquinolines with excellent enantioselectivities through a relay visible-light-induced cyclization/chiral phosphoric acid-catalyzed transfer hydrogenation reaction.
摘要
一种高效的方法，将布朗斯特酸催化与可见光诱导相结合，用于高度对映选择性合成四氢喹啉。该温和的过程通过接力可见光诱导环化/手性磷酸催化转移氢化反应，直接将 2-氨基烯酮转化为具有优异对映选择性的 2-取代四氢喹啉。
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