Gecks Thomas, Prochnau Dirk, Franz Marcus, Jung Christian, Kühnert Helmut, Schliemann Sibylle, Figulla Hans Rainer
Department of Internal Medicine I, Jena University Hospital, Erlanger Allee 101, 07747, Jena, Germany.
Department of Dermatology, Jena University Hospital, Erfurter Straße 35, 07740, Jena, Germany.
Cardiovasc Toxicol. 2015 Oct;15(4):399-401. doi: 10.1007/s12012-014-9303-x.
A 77-year-old female patient with symptomatic atrial fibrillation with fast ventricular rate despite conventional antiarrhythmic therapy was treated with dronedarone. Five days later, she developed a maculopapulous exanthema and small flaccid blisters, which spread over the common integument predominantly located on the dorsal trunk. Over few days, the patient showed a severe epidermal necrolysis of approximately 30 % of the body area and ultimately died in multiorgan failure. Here, we report a rare case of toxic epidermal necrolysis during treatment with dronedarone leading to patient death.
一名77岁女性患者，尽管接受了传统抗心律失常治疗，但仍有症状性房颤且心室率快，接受了决奈达隆治疗。五天后，她出现了斑丘疹和小的松弛水疱，主要分布在躯干背部的普通皮肤表面。几天内，患者出现了约30%体表面积的严重表皮坏死松解，最终死于多器官功能衰竭。在此，我们报告一例决奈达隆治疗期间发生的罕见中毒性表皮坏死松解症导致患者死亡的病例。
