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瑞吡司特对哮喘患者茶碱药代动力学无影响。

Lack of effect of repirinast on the pharmacokinetics of theophylline in asthmatic patients.

作者信息

Takagi K, Kuzuya T, Horiuchi T, Nadai M, Apichartpichean R, Ogura Y, Hasegawa T

机构信息

Second Department of Internal Medicine, Nagoya University School of Medicine, Japan.

出版信息

Eur J Clin Pharmacol. 1989;37(3):301-3. doi: 10.1007/BF00679789.

DOI:10.1007/BF00679789
PMID:2558890
Abstract

A possible pharmacokinetic interaction between theophylline and repirinast has been investigated in asthmatic patients. The kinetics of theophylline was studied in seven adult in-patients given theophylline 400-800 mg b.d. alone and after three weeks of co-administration of repirinast. There was no effect on the kinetics of the combined treatment.

摘要

在哮喘患者中研究了茶碱与瑞吡司特之间可能存在的药代动力学相互作用。对7名成年住院患者进行了研究，这些患者单独每日两次服用400 - 800毫克茶碱，以及在联合服用瑞吡司特三周后，研究了茶碱的动力学。联合治疗对动力学没有影响。

相似文献

1
Lack of effect of repirinast on the pharmacokinetics of theophylline in asthmatic patients.瑞吡司特对哮喘患者茶碱药代动力学无影响。
Eur J Clin Pharmacol. 1989;37(3):301-3. doi: 10.1007/BF00679789.
2
[The influence of repirinast, an anti-allergic drug, on theophylline pharmacokinetics in patients with bronchial asthma].[抗过敏药物瑞吡司特对支气管哮喘患者茶碱药代动力学的影响]
Nihon Kyobu Shikkan Gakkai Zasshi. 1991 Apr;29(4):413-9.
3
Effect of mequitazine on the pharmacokinetics of theophylline in asthmatic patients.美喹他嗪对哮喘患者茶碱药代动力学的影响。
Eur J Clin Pharmacol. 1990;38(3):255-8. doi: 10.1007/BF00315026.
4
Increased theophylline clearance in asthmatic patients due to terbutaline.特布他林导致哮喘患者茶碱清除率增加。
Eur J Clin Pharmacol. 1989;36(1):25-8. doi: 10.1007/BF00561018.
5
Kinetic interaction between theophylline and a newly developed anti-allergic drug, pemirolast potassium.茶碱与新开发的抗过敏药物吡嘧司特钾之间的动力学相互作用。
Eur J Clin Pharmacol. 1994;46(1):55-8. doi: 10.1007/BF00195916.
6
[The pharmacokinetics of theopek--a new Soviet prolonged-action drug form of theophylline--in patients with bronchial asthma].[茶喘平——一种苏联新型长效茶碱剂型——在支气管哮喘患者中的药代动力学]
Farmakol Toksikol. 1989 Sep-Oct;52(5):63-8.
7
Effect of a new quinolone, sparfloxacin, on the pharmacokinetics of theophylline in asthmatic patients.新型喹诺酮类药物司帕沙星对哮喘患者茶碱药代动力学的影响。
Antimicrob Agents Chemother. 1991 Jun;35(6):1137-41. doi: 10.1128/AAC.35.6.1137.
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Studies on the pharmacokinetics of theophylline in asthmatic patients following multiple oral dosing of a sustained-release theophylline tablet formulation.对哮喘患者多次口服缓释茶碱片制剂后茶碱的药代动力学研究。
Arerugi. 1985 Nov;34(11):1006-14.
9
Studies on the pharmacokinetics of theophylline and its effect on respiratory impedance in asthmatic patients after multiple oral dosing of a sustained-release theophylline tablet formulation.多次口服缓释茶碱片制剂后茶碱的药代动力学及其对哮喘患者呼吸阻抗影响的研究。
Arerugi. 1986 May;35(5):320-8.
10
[The effect of mexiletine on theophylline pharmacokinetics in patients with bronchial asthma].[美西律对支气管哮喘患者茶碱药代动力学的影响]
J Cardiol. 1992;22(1):227-33.

引用本文的文献

1
Kinetic interaction between theophylline and a newly developed anti-allergic drug, pemirolast potassium.茶碱与新开发的抗过敏药物吡嘧司特钾之间的动力学相互作用。
Eur J Clin Pharmacol. 1994;46(1):55-8. doi: 10.1007/BF00195916.
2
Effect of mequitazine on the pharmacokinetics of theophylline in asthmatic patients.美喹他嗪对哮喘患者茶碱药代动力学的影响。
Eur J Clin Pharmacol. 1990;38(3):255-8. doi: 10.1007/BF00315026.
3
Pharmacokinetic interactions between theophylline and other medication (Part II).茶碱与其他药物之间的药代动力学相互作用（第二部分）。

本文引用的文献

1
Inhibition of theophylline metabolism by long-term allopurinol administration.长期服用别嘌醇对茶碱代谢的抑制作用。
Clin Pharmacol Ther. 1981 Feb;29(2):224-9. doi: 10.1038/clpt.1981.36.
2
Evaluation of "toxic" serum theophylline concentrations.“毒性”血清茶碱浓度的评估
Am J Hosp Pharm. 1981 Aug;38(8):1164-6.
3
Effect of erythromycin on theophylline clearance in asthmatic children.
J Pediatr. 1981 Jul;99(1):153-6. doi: 10.1016/s0022-3476(81)80983-3.
Clin Pharmacokinet. 1991 Feb;20(2):135-50. doi: 10.2165/00003088-199120020-00005.
4
Pharmacokinetics of the active metabolite of the prodrug repirinast in healthy Caucasian volunteers after a single oral dose.前药瑞吡司特的活性代谢产物在健康白种人志愿者单次口服给药后的药代动力学。
Eur J Clin Pharmacol. 1992;42(3):307-12. doi: 10.1007/BF00266353.
4
Cimetidine decreases theophylline clearance.西咪替丁降低茶碱清除率。
Am Rev Respir Dis. 1981 Jun;123(6):615-7. doi: 10.1164/arrd.1981.123.6.615.
5
Pharmacokinetic drug interactions with theophylline.与茶碱的药代动力学药物相互作用。
Clin Pharmacokinet. 1984 Jul-Aug;9(4):309-34. doi: 10.2165/00003088-198409040-00002.
6
Pharmacokinetics of theophylline. Application to adjustment of the clinical dose of aminophylline.茶碱的药代动力学。在氨茶碱临床剂量调整中的应用。
Clin Pharmacol Ther. 1972 May-Jun;13(3):349-60. doi: 10.1002/cpt1972133349.
7
Rational intravenous doses of theophylline.氨茶碱的合理静脉给药剂量。
N Engl J Med. 1973 Sep 20;289(12):600-3. doi: 10.1056/NEJM197309202891202.
8
Determination of the central effects of the asthma prophylactic ketotifen, the bronchodilator theophylline, and both in combination: an application of quantitative electroencephalography to the study of drug interactions.哮喘预防药物酮替芬、支气管扩张剂茶碱及其联合使用的中枢效应测定：定量脑电图在药物相互作用研究中的应用
Int J Clin Pharmacol Ther Toxicol. 1985 May;23(5):258-66.
9
Enoxacin decreases the clearance of theophylline in man.依诺沙星可降低人体中茶碱的清除率。
Br J Clin Pharmacol. 1985 Dec;20(6):583-8. doi: 10.1111/j.1365-2125.1985.tb05115.x.
10
Study of drug interaction between the new antiallergic drug 11-oxo-11H-pyrido[2,1-b]quinazoline-2-carboxylic acid and theophylline.新型抗过敏药物11-氧代-11H-吡啶并[2,1-b]喹唑啉-2-羧酸与茶碱的药物相互作用研究。
Arzneimittelforschung. 1986 Nov;36(11):1642-6.