Fukagawa Y, Katz J L, Suzuki T
Department of Pharmacology, Hoshi University, Japan.
Eur J Pharmacol. 1989 Oct 24;170(1-2):47-51. doi: 10.1016/0014-2999(89)90132-5.
Rats were made dependent on morphine by mixing the drug with their only source of food. Naltrexone (0.5 mg/kg) injection precipitated a syndrome of withdrawal signs including weight loss. Pretreatment with the selective kappa agonist, U-50,488H (1.0, 30.0 or 10.0 mg/kg), generally had no effects on the signs of morphine withdrawal. In other subjects, U-50,488H was repeatedly administered (1.0, 3.0 or 10.0 mg/kg per 12 h) during the development of morphine dependence. In these subjects, the course of naltrexone-precipitated withdrawal was unchanged. These results suggest that agonist activity at kappa receptors is not sufficient to alter morphine dependence or withdrawal.
通过将吗啡与大鼠唯一的食物来源混合，使大鼠对吗啡产生依赖。注射纳曲酮（0.5毫克/千克）引发了包括体重减轻在内的戒断症状综合征。用选择性κ阿片受体激动剂U-50,488H（1.0、30.0或10.0毫克/千克）进行预处理，通常对吗啡戒断症状没有影响。在其他实验对象中，在吗啡依赖形成过程中反复给予U-50,488H（每12小时1.0、3.0或10.0毫克/千克）。在这些实验对象中，纳曲酮引发的戒断过程没有改变。这些结果表明，κ阿片受体的激动剂活性不足以改变吗啡依赖或戒断。
