Wood Brian R, Lacy John Matthew, Johnston Christine, Weigle David S, Dhanireddy Shireesha
Division of Allergy and Infectious Disease, University of Washington, Seattle, WA, USA
Department of Pathology, University of Washington, Seattle, WA, USA.
J Int Assoc Provid AIDS Care. 2015 Jul-Aug;14(4):300-5. doi: 10.1177/2325957414567681. Epub 2015 Jan 14.
Numerous cases of Cushing syndrome have been reported as a result of the interaction between ritonavir (RTV) and exogenous steroid medications. Another complication that frequently occurs is secondary adrenal insufficiency, which can be profound and has not been well described. Here, we report 6 cases of adrenal suppression caused by RTV and exogenous steroids, all of which required corticosteroid replacement therapy and 2 of which were severe enough to require hospitalization. These cases add to the body of literature on the dangerous interaction between RTV and corticosteroids and highlight the risk of secondary adrenal suppression. We also review the literature on this complication and make a recommendation for managing and monitoring such cases.
已报告了许多因利托那韦（RTV）与外源性类固醇药物相互作用导致库欣综合征的病例。另一种经常出现的并发症是继发性肾上腺功能不全，其可能很严重且尚未得到充分描述。在此，我们报告6例由RTV和外源性类固醇引起的肾上腺抑制病例，所有这些病例均需要皮质类固醇替代治疗，其中2例严重到需要住院治疗。这些病例补充了关于RTV与皮质类固醇之间危险相互作用的文献，并突出了继发性肾上腺抑制的风险。我们还回顾了关于这一并发症的文献，并对管理和监测此类病例提出了建议。
