Huguet F
Institut du Médicament de Tours, Saint-Pierre-des-Corps, Tours, France.
Fundam Clin Pharmacol. 1989;3 Suppl:31s-46s. doi: 10.1111/j.1472-8206.1989.tb00473.x.
Recent advances in central dihydropyridine (DHP)-binding sites are reviewed. DHP-binding sites are pre-synaptically and post-synaptically localized in the brain. The functional role of post-synaptic sites is still unknown, whereas pre-synaptic sites seem to contribute to the control of calcium uptake and of neurotransmitter release. DHP-binding sites may be modualated in physiological (age, sex) and pathological events (hypertension, ischaemia, neurological diseases) or after drug treatments (alcohol, morphine, etc.). The reviewed data suggest new therapeutic implications of DHP calcium channel antagonists in the treatment of other diseases and of drug withdrawal syndrome.
本文综述了中枢二氢吡啶（DHP）结合位点的最新进展。DHP结合位点在大脑中定位于突触前和突触后。突触后位点的功能作用尚不清楚，而突触前位点似乎有助于控制钙摄取和神经递质释放。DHP结合位点可能在生理（年龄、性别）和病理事件（高血压、缺血、神经疾病）或药物治疗（酒精、吗啡等）后受到调节。综述数据表明DHP钙通道拮抗剂在治疗其他疾病和药物戒断综合征方面具有新的治疗意义。
