De França Natasha A G, Camargo Marilia B R, Lazaretti-Castro Marise, Martini Lígia Araújo
Department of Nutrition, School of Public Health, Sao Paulo University, Sao Paulo, Brazil Food and Nutrition Research Center (NAPAN), Sao Paulo, Brazil.
Division of Endocrinology, School of Medicine, Federal University of Sao Paulo, Sao Paulo, Brazil.
Nutr Health. 2013 Apr;22(2):133-42. doi: 10.1177/0260106014563445. Epub 2015 Jan 14.
This study aimed to investigate the association between antioxidant intake and bone mineral density (BMD) in postmenopausal women with osteoporosis. We conducted a cross-sectional study with 150 women, mean age 68.7 (SD 9.1) years. BMD and body composition were obtained using dual-energy X-ray absorptiometry (DXA). We assessed anthropometric measures and dietary intake and applied an adapted Dietary Antioxidant Quality Score (a-DAQS) to evaluate the antioxidant consumption. 65.3% of women had higher scores on the a-DAQS. We found no relationship between the a-DAQS and BMD; however, we observed an inverse correlation between vitamin A and lumbar spine (LS) BMD in g/cm(2) (r = - 0.201; p = 0.013). An analysis of variance (ANOVA) test also showed that vitamin A was negatively associated with the LS BMD (F = 6.143; p = 0.013, but without significance when a multivariate analysis was applied. The a-DAQS did not have an association with BMD; however, Vitamin A showed a negative correlation with BMD, but such an association disappeared when the other antioxidants were taken together. Our findings encourage an antioxidant-based dietary approach to osteoporosis prevention and treatment, since the negative effect of vitamin A was neutralized by the intake of such nutrients.
本研究旨在调查骨质疏松症绝经后女性抗氧化剂摄入量与骨矿物质密度（BMD）之间的关联。我们对150名女性进行了一项横断面研究，她们的平均年龄为68.7（标准差9.1）岁。使用双能X线吸收法（DXA）测量骨密度和身体成分。我们评估了人体测量指标和饮食摄入量，并应用改良的膳食抗氧化质量评分（a-DAQS）来评估抗氧化剂的摄入量。65.3%的女性在a-DAQS上得分较高。我们发现a-DAQS与骨密度之间没有关系；然而，我们观察到维生素A与腰椎（LS）骨密度（单位：g/cm²）之间存在负相关（r = - 0.201；p = 0.013）。方差分析（ANOVA）测试还表明，维生素A与腰椎骨密度呈负相关（F = 6.143；p = 0.013，但在进行多变量分析时无显著性）。a-DAQS与骨密度没有关联；然而，维生素A与骨密度呈负相关，但当同时摄入其他抗氧化剂时，这种关联消失。我们的研究结果鼓励采用基于抗氧化剂的饮食方法来预防和治疗骨质疏松症，因为维生素A的负面影响会被这些营养素的摄入所抵消。
