Center for Food and Nutritional Genomics Research, Kyungpook National University, Daegu 41566, Korea.
Department of Food Science and Nutrition, Kyungpook National University, Daegu 41566, Korea.
Nutrients. 2021 Aug 24;13(9):2926. doi: 10.3390/nu13092926.
Menopause is a matter of concern for women's health due to a deficiency of female hormones; additionally, reactive oxygen species and aging can cause osteoporosis. Food becomes increasingly interesting as a menopausal woman's alternative to hormone therapy. The effects of ethanol extracts from dark purple Superjami rice bran on bone metabolism and antioxidant defense systems in menopause-induced animal models were evaluated. Female rats underwent sham surgery or were ovariectomized to induce a menopause-like state. Rats were divided into a sham control group (SHAM), an ovariectomized control group (OVX), and an ovariectomized grou supplemented with Superjami rice bran extract group (OVX-S) and fed for 8 weeks. The OVX groups exhibited significantly more weight gain, amounts of bone turnover biochemical markers (alkaline phosphatase, osteocalcin, and C-terminal telopeptide), bone loss, lipid-peroxidation and oxidative stress than the SHAM group. However, Superjami bran extract added to the diet resulted in a significant reduction in body weight and lipid peroxidation, as well as enhanced bone metabolism and antioxidant enzyme activities, in ovariectomized rats. These results propound that extracts from Superjami rice bran have therapeutic potentiality against bone loss and oxidative stress in menopause-induced states and will be useful in preventing postmenopausal osteoporosis and oxidative damage.
绝经是女性健康关注的问题，因为女性激素缺乏；此外，活性氧和衰老会导致骨质疏松。食物作为绝经后女性激素替代疗法的替代品变得越来越有趣。评估了黑米糠乙醇提取物对绝经诱导动物模型骨代谢和抗氧化防御系统的影响。雌性大鼠接受假手术或卵巢切除术以诱导绝经样状态。大鼠分为假手术对照组（SHAM）、卵巢切除术对照组（OVX）和卵巢切除术补充黑米糠提取物组（OVX-S），并喂养 8 周。OVX 组的体重增加、骨转换生化标志物（碱性磷酸酶、骨钙素和 C 端肽）、骨丢失、脂质过氧化和氧化应激明显高于 SHAM 组。然而，饮食中添加黑米糠提取物可显著降低卵巢切除大鼠的体重和脂质过氧化，并增强骨代谢和抗氧化酶活性。这些结果表明，黑米糠提取物具有治疗绝经诱导状态下骨丢失和氧化应激的潜力，将有助于预防绝经后骨质疏松症和氧化损伤。
