海马体CA1区细胞内钙含量的升高与长时程增强的发展并无直接关联。

Elevation of intracellular calcium content in area CA1 of hippocampus is not directly correlated with the development of long-term potentiation.

作者信息

Siklós L, Kuhnt U, Mihály A, Joó F

机构信息

Institute of Biophysics, Biological Research Center, Szeged, Hungary.

出版信息

Neurosci Lett. 1989 Dec 15;107(1-3):99-104. doi: 10.1016/0304-3940(89)90798-2.

DOI:10.1016/0304-3940(89)90798-2

PMID:2559374

Abstract

Electron microscopic localization of calcium-containing mitochondria in stratum radiatum of CAl of hippocampal slices was performed after (1) low-frequency stimulation, (2) high-frequency stimulation, and (3) blocking N-methyl-D-aspartate (NMDA) receptors during high-frequency stimulation. Dendritic mitochondria containing Ca deposits were found in a narrow band of stratum radiatum 280-350 microns distant from stratum pyramidale. Axonal mitochondria containing Ca deposits were evenly distributed in stratum radiatum. The total number of calcium containing-mitochondria was highest in long-term potentiated slices, and less in slices treated with APV; the lowest values were obtained with low-frequency stimulation.

摘要

在以下三种情况下对海马切片CA1区辐射层中含钙线粒体进行电子显微镜定位：（1）低频刺激后；（2）高频刺激后；（3）高频刺激期间阻断N-甲基-D-天冬氨酸（NMDA）受体后。在距锥体层280 - 350微米的辐射层窄带中发现含有钙沉积物的树突线粒体。含有钙沉积物的轴突线粒体均匀分布在辐射层中。长期增强切片中含钙线粒体的总数最高，而用APV处理的切片中较少；低频刺激后得到的值最低。