Chang K J, Saito H, Tatsuno I, Tamura Y, Watanabe K, Yoshida S
Second Department of Internal Medicine, School of Medicine, Chiba University, Japan.
Prostaglandins Leukot Essent Fatty Acids. 1989 Nov;38(2):87-90. doi: 10.1016/0952-3278(89)90090-2.
We compared in vitro effect of lipoxygenase (LO) products derived from arachidonic acid (AA) and eicosapentaenoic acid (EPA) on cytotoxic activity of human natural killer (NK) cell against human erythroleukemia cell line K-562. Leukotriene B4 (LTB4) derived from AA was found to significantly augment NK cell activity compared to the control level (in the absence of LTB). LTB5 showed a weak, but not significant, enhancing effect on NK cell activity. LTB4 was significantly more potent than LTB5 in the enhancement of NK cell activity. On the other hand, both 5- and 15-hydroperoxy fatty acids derived from AA and EPA significantly enhanced NK cell activity compared to the control level with similar potencies.
我们比较了源自花生四烯酸（AA）和二十碳五烯酸（EPA）的脂氧合酶（LO）产物对人自然杀伤（NK）细胞针对人红白血病细胞系K - 562的细胞毒性活性的体外作用。发现源自AA的白三烯B4（LTB4）与对照水平（不存在LTB）相比，显著增强了NK细胞活性。LTB5对NK细胞活性显示出微弱但不显著的增强作用。在增强NK细胞活性方面，LTB4比LTB5显著更有效。另一方面，源自AA和EPA的5 - 氢过氧脂肪酸和15 - 氢过氧脂肪酸与对照水平相比，均以相似的效力显著增强了NK细胞活性。
