Nakano Yousuke, Furube Eriko, Morita Shoko, Wanaka Akio, Nakashima Toshihiro, Miyata Seiji
Department of Applied Biology, Kyoto Institute of Technology, Matsugasaki, Sakyo-ku, Kyoto 606-8585, Japan.
The Department of Anatomy and Neuroscience, Faculty of Medicine, Nara Medical University, Shijo-cho, Kashihara, Nara 634-8521, Japan.
J Neuroimmunol. 2015 Jan 15;278:144-58. doi: 10.1016/j.jneuroim.2014.12.013. Epub 2014 Dec 16.
The sensory circumventricular organs (CVOs) comprise the organum vasculosum of the lamina terminalis (OVLT), subfornical organ (SFO), and area postrema (AP) and lack the blood-brain barrier. The expression of Toll-like receptor 4 (TLR4) was seen at astrocytes throughout the sensory CVOs and at microglia in the AP and solitary nucleus around the central canal. The peripheral and central administration of lipopolysaccharide induced a similar pattern of nuclear translocation of STAT3. A microglia inhibitor minocycline largely suppressed lipopolysaccharide-induced astrocytic nuclear translocation of STAT3 in the OVLT and AP, but its effect was less in the SFO.
感觉性室周器官（CVOs）包括终板血管器（OVLT）、穹窿下器官（SFO）和最后区（AP），且缺乏血脑屏障。在整个感觉性CVOs的星形胶质细胞以及AP和中央管周围孤束核的小胶质细胞中均可见Toll样受体4（TLR4）的表达。外周和中枢给予脂多糖诱导了相似的信号转导和转录激活因子3（STAT3）核转位模式。小胶质细胞抑制剂米诺环素在很大程度上抑制了脂多糖诱导的OVLT和AP中星形胶质细胞的STAT3核转位，但在SFO中的作用较小。
