Bryson D G, McNulty M S, Evans R T, Allan G
Department of Agriculture, Veterinary Research Laboratories, Stormont, Belfast.
Vet Rec. 1989 Dec 16;125(25):615-8.
The effect of the administration of recombinant human interferon on the severity of clinical disease and the extent of pneumonic lesions in calves infected experimentally with bovine parainfluenza 3 (PI3) virus was studied in two experiments. In the first, three pairs of calves aged seven to 10 days were used; one of each pair was injected intramuscularly with 10(6) units of interferon/kg bodyweight for three consecutive days, and the other was left untreated. On the day after the first injection of interferon all the calves were challenged with PI3 virus, a different dose being administered to each pair. There was no evidence of any protective effect from the treatment with interferon. The second experiment used eight, six-week-old calves; four were inoculated in the same way with interferon and all the calves were challenged with the same dose of PI3. Again, there was no evidence of a reduction either in the severity of clinical disease or in the extent of lung consolidation in the calves treated with interferon.
在两项实验中研究了重组人干扰素给药对实验感染牛副流感3型（PI3）病毒的犊牛临床疾病严重程度和肺部病变范围的影响。在第一项实验中，使用了三对7至10日龄的犊牛；每对中的一头连续三天肌肉注射10⁶单位干扰素/千克体重，另一头不进行治疗。在首次注射干扰素后的第二天，所有犊牛都用PI3病毒进行攻击，每对给予不同剂量。没有证据表明干扰素治疗有任何保护作用。第二项实验使用了八头六周龄的犊牛；四头以相同方式接种干扰素，所有犊牛都用相同剂量的PI3进行攻击。同样，没有证据表明接受干扰素治疗的犊牛临床疾病严重程度或肺部实变范围有所降低。
