Straub O C
BFAV, Tübingen, Germany.
Comp Immunol Microbiol Infect Dis. 1995 Sep;18(4):239-43. doi: 10.1016/0147-9571(95)00013-x.
Twelve cattle with body wts ranging from 100 to 250 kg were treated using various doses and routes for four days with an E. coli derived alpha-hybrid interferon. The lowest parenteral doses (10(4) units per kg body wt) and the orally administered interferon did not lead to any disturbances, whereas the higher dosages led to marked changes in body temperature, pulse and respiration rates. Animals with the highest dose (10(8) units per kg body wt) became extremely distressed. The blood picture showed distinct changes, with very low leukocyte counts during treatment, which took weeks to recover. It is suggested that the dosages that did not lead to clinical symptoms are best suited for prophylactic or therapeutic purposes.
选用体重在100至250公斤之间的12头牛，使用不同剂量和途径，用大肠杆菌衍生的α-杂交干扰素治疗四天。最低的肠胃外给药剂量（每公斤体重10⁴单位）和口服干扰素未导致任何不适，而较高剂量导致体温、脉搏和呼吸频率显著变化。接受最高剂量（每公斤体重10⁸单位）的动物极度痛苦。血液检查显示出明显变化，治疗期间白细胞计数极低，需要数周才能恢复。建议未导致临床症状的剂量最适合用于预防或治疗目的。
