维生素D浓度与不同维生素D受体基因多态性（rs10735810、rs1544410、rs7975232、rs731236）基因型的波兰老年人群中性激素水平之间的关联。
Association between vitamin D concentration and levels of sex hormones in an elderly Polish population with different genotypes of VDR polymorphisms (rs10735810, rs1544410, rs7975232, rs731236).
作者信息
Laczmanski Lukasz, Lwow Felicja, Mossakowska Malgorzata, Puzianowska-Kuznicka Monika, Szwed Małgorzata, Kolackov Katarzyna, Krzyzanowska-Swiniarska Barbara, Bar-Andziak Ewa, Chudek Jerzy, Sloka Natalia, Milewicz Andrzej
机构信息
Department of Endocrinology and Diabetology, Wroclaw Medical University, Wroclaw, Poland.
Department of Health Promotion, Faculty of Physiotherapy, University School of Physical Education, Wroclaw, Poland.
出版信息
Gene. 2015 Mar 15;559(1):73-6. doi: 10.1016/j.gene.2015.01.022. Epub 2015 Jan 14.
BACKGROUND
Vitamin D co-regulates the synthesis of sex hormones in part by interaction with its nuclear receptor. The aim of this study was to determine whether there is an association of vitamin D concentration vs the level of sex hormones in elderly Polish individuals with different genotypes of the vitamin D receptor (VDR) gene.
MATERIALS AND METHODS
Rs10735810, rs1544410, rs7975232, and rs731236 polymorphisms of VDR, the serum sex hormone level, free estrogen index (FEI) and free androgen index (FAI) as well as vitamin D, were evaluated in 766 persons (362 women and 404 men) selected from 5695 Polish population, aged 65-90years from the PolSenior survey.
RESULTS
We observed that women with GG (rs731236), TT (rs7975232), BB (rs1544410) and FF (rs10735810) genotypes were characterized by a significant correlation between vitamin D vs testosterone concentration and FAI value. We found a significant correlation between testosterone level and FAI vs vitamin D concentration in men with heterozygote AG in the rs731236 polymorphism and in the GG (rs7975232), the BB (rs1544410), and the Ff (rs10735810) genotypes.
CONCLUSION
In elderly selected Polish population with different genotypes of VDR polymorphisms, a statistically significant relationship between vitamin D concentration vs testosterone level was observed.
背景
维生素D部分通过与其核受体相互作用来共同调节性激素的合成。本研究的目的是确定在具有不同维生素D受体（VDR）基因基因型的波兰老年人中，维生素D浓度与性激素水平之间是否存在关联。
材料与方法
从波兰老年调查中选取的5695名波兰人群中选出766人（362名女性和404名男性），年龄在65 - 90岁，对其VDR的rs10735810、rs1544410、rs7975232和rs731236多态性、血清性激素水平、游离雌激素指数（FEI）和游离雄激素指数（FAI）以及维生素D进行评估。
结果
我们观察到，具有GG（rs731236）、TT（rs7975232）、BB（rs1544410）和FF（rs10735810）基因型的女性，其维生素D与睾酮浓度及FAI值之间存在显著相关性。我们发现，在rs731236多态性中具有杂合子AG以及具有GG（rs7975232）、BB（rs1544410）和Ff（rs10735810）基因型的男性中，睾酮水平和FAI与维生素D浓度之间存在显著相关性。
结论
在具有不同VDR多态性基因型的波兰老年人群中，观察到维生素D浓度与睾酮水平之间存在统计学上的显著关系。
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