Björkhem-Bergman Linda, Lehtihet Mikael, Rane Anders, Ekström Lena
Division of Clinical Microbiology F68, Department of Laboratory Medicine, Karolinska University Hospital, Karolinska Institutet, Huddinge, 141 86, Stockholm, Sweden.
Department of Medicine, Division of Endocrinology, Metabolism and Diabetesm Karolinska Institutet, Karolinska University Hospital, Huddinge, 141 86, Stockholm, Sweden.
BMC Res Notes. 2018 Jan 19;11(1):51. doi: 10.1186/s13104-018-3173-4.
The primary aim of this study was to investigate the association between the vitamin D receptor polymorphisms rs2228570 (Fok1) and rs731236 (TaqI) and LH and FSH levels in relation to anabolic androgenic steroid (AAS) use.
Two cohorts were analyzed. Cohort 1 comprised healthy volunteers given single supra-physiological doses of 500 mg testosterone (n = 25). Cohort 2 comprised 45 self-reporting AAS users. Healthy volunteers homozygous for the C-allele of the Fok1 polymorphism exhibited 30% higher LH levels than T-carriers at baseline (p = 0.04) and twice the levels 14 days after testosterone administration (p = 0.01). AAS users homozygous for the C-allele had four times higher LH levels than TT-individuals (p < 0.05). FSH levels were not associated with Fok1 polymorphism, nor were LH and FSH levels associated with the TaqI polymorphism. In conclusion, there is an association between LH levels and the Fok1 VDR polymorphism and this difference is even more pronounced in AAS users and subjects with suppressed LH levels.
本研究的主要目的是调查维生素D受体基因多态性rs2228570（Fok1）和rs731236（TaqI）与合成代谢雄激素类固醇（AAS）使用相关的促黄体生成素（LH）和促卵泡生成素（FSH）水平之间的关联。
分析了两个队列。队列1包括给予单次超生理剂量500毫克睾酮的健康志愿者（n = 25）。队列2包括45名自我报告的AAS使用者。Fok1多态性C等位基因纯合的健康志愿者在基线时LH水平比T等位基因携带者高30%（p = 0.04），在给予睾酮14天后LH水平是后者的两倍（p = 0.01）。Fok1多态性C等位基因纯合的AAS使用者LH水平比TT个体高四倍（p < 0.05）。FSH水平与Fok1多态性无关，LH和FSH水平也与TaqI多态性无关。总之，LH水平与Fok1维生素D受体多态性之间存在关联，这种差异在AAS使用者和LH水平受抑制的受试者中更为明显。
