[四氧嘧啶对体外磷代谢各种酶活性的影响]
[The effect of alloxan on activity of various enzymes of phosphorus metabolism in vitro].
作者信息
Parsadanian G K, Sarkisian L V, Aslanian I G, Adunts G T, Adunts G G
出版信息
Vopr Med Khim. 1989 Sep-Oct;35(5):23-6.
PMID:2559547
Abstract
Effect of alloxan on activity of acetylphosphatase, alkaline and acid phosphatases, phenylpyrophosphatase was studied in vitro. Alloxan at concentrations 100 microM-10 mM inhibited acid phosphatase and especially alkaline phosphatase. Reducing agents (pyrocatechol, hydroquinone, ascorbic acid), which are easily converted into corresponding oxidized forms, at concentrations 100 microM-1.0 mM activated alkaline phosphatase in rat kidney and small intestine.
摘要
在体外研究了四氧嘧啶对乙酰磷酸酶、碱性磷酸酶、酸性磷酸酶和苯基焦磷酸酶活性的影响。浓度为100微摩尔/升至10毫摩尔/升的四氧嘧啶抑制酸性磷酸酶，尤其是碱性磷酸酶。易转化为相应氧化形式的还原剂（邻苯二酚、对苯二酚、抗坏血酸），浓度为100微摩尔/升至1.0毫摩尔/升时，可激活大鼠肾脏和小肠中的碱性磷酸酶。
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