Ihara T, Kamiya H, Starr S E, Arbeter A M, Lange B
Acta Paediatr Jpn. 1989 Oct;31(5):523-8. doi: 10.1111/j.1442-200x.1989.tb01349.x.
We studied mononuclear cell (MNC)-mediated natural killing (NK) of varicella-zoster virus (VZV)-infected fibroblasts in normal children, children with VZV infections, and children with Hodgkin's disease. NK activity was tested in 18 hr 51Cr release assays. NK activity for adults was significantly higher than that for children 1-3 years old or 4-6 years old (p less than 0.05). Serological status did not affect NK activity. NK activity in normal children was not increased 4-6 weeks after immunization with varicella vaccine. Seven normal children with natural varicella showed significantly higher NK activity against VZV-infected and uninfected targets. Eight immunosuppressed children with herpes zoster showed significantly reduced NK activity within 72 hours of the onset of herpes zoster. However, their NK activity rose to the normal level one to two weeks later. Children with Hodgkin's disease had low NK activity. These results suggested that NK cells might play an initial defensive role in VZV infections, and that low NK activity in immunocompromised hosts might contribute to their high incidence of herpes zoster.
我们研究了正常儿童、水痘-带状疱疹病毒（VZV）感染儿童及霍奇金病患儿中单核细胞（MNC）介导的对VZV感染成纤维细胞的自然杀伤（NK）作用。在18小时的51Cr释放试验中检测NK活性。成人的NK活性显著高于1 - 3岁或4 - 6岁的儿童（p < 0.05）。血清学状态不影响NK活性。正常儿童接种水痘疫苗4 - 6周后NK活性未增加。7名自然感染水痘的正常儿童对VZV感染和未感染的靶细胞表现出显著更高的NK活性。8名免疫抑制的带状疱疹患儿在带状疱疹发作72小时内NK活性显著降低。然而，一到两周后他们的NK活性升至正常水平。霍奇金病患儿的NK活性较低。这些结果表明NK细胞可能在VZV感染中发挥初始防御作用，免疫功能低下宿主中NK活性降低可能导致其带状疱疹高发。
