Department of Pediatrics, University of Colorado Denver, Aurora, Colorado, USA.
J Infect Dis. 2010 Apr 1;201(7):1024-30. doi: 10.1086/651199.
Varicella-zoster virus (VZV)-specific cell-mediated immunity is important for protection against VZV disease. We studied the relationship between VZV cell-mediated immunity and age after varicella or VZV vaccination in healthy and human immunodeficiency virus (HIV)-infected individuals.
VZV responder cell frequency (RCF) determinations from 752 healthy and 200 HIV-infected subjects were used to identify group-specific regression curves on age.
In healthy individuals with past varicella, VZV RCF peaked at 34 years of age. Similarly, VZV-RCF after varicella vaccine increased with age in subjects aged <1 to 43 years. In subjects aged 61-90 years, VZV RCF after zoster vaccine decreased with age. HIV-infected children had lower VZV RCF estimates than HIV-infected adults. In both groups, VZV RCF results were low and constant over age. Varicella vaccination of HIV-infected children with CD4 levels 20% generated VZV RCF values higher than wild-type infection and comparable to vaccine-induced responses of healthy children.
In immunocompetent individuals with prior varicella, VZV RCF peaked in early adulthood. Administration of varicella vaccine to HIV-infected or uninfected individuals aged >5 years generated VZV RCF values similar to those of immunocompetent individuals with immunity induced by wild-type infection. A zoster vaccine increased the VZV RCF of elderly adults aged <75 years to values higher than peak values induced by wild-type infection.
水痘带状疱疹病毒（VZV）特异性细胞介导的免疫对于预防 VZV 疾病至关重要。我们研究了在健康个体和人类免疫缺陷病毒（HIV）感染者中，水痘或 VZV 疫苗接种后 VZV 细胞介导免疫与年龄的关系。
我们对 752 名健康个体和 200 名 HIV 感染者的 VZV 反应细胞频率（RCF）进行了测定，以确定年龄的组特异性回归曲线。
在有既往水痘病史的健康个体中，VZV RCF 在 34 岁时达到峰值。同样，在年龄<1 至 43 岁的个体中，水痘疫苗后的 VZV-RCF 随着年龄的增长而增加。在年龄 61-90 岁的个体中，带状疱疹疫苗后的 VZV RCF 随着年龄的增长而下降。HIV 感染儿童的 VZV RCF 估计值低于 HIV 感染成人。在这两个群体中，VZV RCF 结果随着年龄的增长而保持低值且稳定。对 CD4 水平为 20%的 HIV 感染儿童进行水痘疫苗接种可产生高于野生型感染的 VZV RCF 值，与健康儿童的疫苗诱导反应相当。
在有既往水痘病史的免疫功能正常个体中，VZV RCF 在成年早期达到峰值。对年龄>5 岁的 HIV 感染者或未感染者接种水痘疫苗可产生与免疫功能正常个体的野生型感染诱导的 VZV RCF 值相似的 VZV RCF 值。带状疱疹疫苗可将年龄<75 岁的老年个体的 VZV RCF 提高到高于野生型感染诱导的峰值水平。
