Ribeiro L M
Acta Med Port. 1989 Mar-Apr;2(2):93-102.
Free radicals are highly reactive molecules, and therefore transient, which have an odd number of electrons and are generated in vivo as byproducts of normal metabolism. In this review we survey basic concepts on the chemistry of oxygen free radicals, their cellular sources and the reactions they can undergo. We also discuss the cellular defenses against free radicals induced damage. The disfunction induced by free radicals may thus be a major component of several pathological conditions. The critical role played by free radicals in ageing, carcinogenesis, reperfusion injury and and respiratory distress is reviewed.
自由基是高反应性分子，因而具有短暂性，它们有奇数个电子，作为正常新陈代谢的副产物在体内生成。在本综述中，我们概述了关于氧自由基化学的基本概念、其细胞来源以及它们可能发生的反应。我们还讨论了细胞对自由基诱导损伤的防御机制。自由基诱导的功能障碍可能是几种病理状况的主要组成部分。本文综述了自由基在衰老、致癌作用、再灌注损伤和呼吸窘迫中所起的关键作用。
