Roma Andres A, Masand Ramya P
Department of Anatomic Pathology, Robert J Tomsich Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, OH.
Department of Pathology & Immunology, Baylor College of Medicine, Houston, TX.
Ann Diagn Pathol. 2015 Feb;19(1):29-32. doi: 10.1016/j.anndiagpath.2014.12.002. Epub 2014 Dec 20.
The association of ovarian Brenner tumors and adjacent mucinous tumors is well known but not completely understood. In this study, we analyzed immunohistochemical markers on Brenner tumors and their associated mucinous tumor to explore Mullerian as well as Wolffian and germ cell derivation and determine if the mucinous component is independent or related to the Brenner tumor. Of 32 consecutive cases of Brenner tumors, 8 were identified with significant mucinous component, and 7 additional cases included foci of mucinous epithelium within the Brenner transitional nests. All Brenner tumors were diffusely positive for GATA3 and negative for Paired box gene 8, PAX2, and Sal-like protein 4. Interestingly, the areas of mucinous epithelium as well as mucinous tumors, intermixed and adjacent to the Brenner tumor, were negative for all 4 markers; however, occasional basal-like cells retained expression of GATA3. The immunoprofile of mucinous tumors associated with Brenner tumors shares the lack of Mullerian markers PAX2 and Paired box gene 8 with the Brenner tumor but differs in the expression of GATA3 only in the Brenner tumor component.
卵巢布伦纳瘤与相邻黏液性肿瘤的关联已为人熟知，但尚未完全明晰。在本研究中，我们分析了布伦纳瘤及其相关黏液性肿瘤的免疫组化标志物，以探究苗勒管、沃尔夫管及生殖细胞的起源，并确定黏液性成分是独立于布伦纳瘤还是与之相关。在连续的32例布伦纳瘤病例中，8例被发现有显著的黏液性成分，另外7例在布伦纳移行巢内包含黏液上皮灶。所有布伦纳瘤GATA3弥漫性阳性，配对盒基因8、PAX2和Sall样蛋白4阴性。有趣的是，与布伦纳瘤混合及相邻的黏液上皮区域以及黏液性肿瘤，这4种标志物均为阴性；然而，偶尔的基底样细胞保留GATA3表达。与布伦纳瘤相关的黏液性肿瘤的免疫表型与布伦纳瘤一样缺乏苗勒管标志物PAX2和配对盒基因8，但仅在布伦纳瘤成分中GATA3表达不同。
