Department of Internal Medicine, National Center for Global Health and Medicine Kohnodai Hospital, Chiba, Japan Division of Complementary Medicine, First Department of General Medicine, Saitama Medical Center, Jichi Medical University School of Medicine, Saitama, Japan.
Department of Internal Medicine, National Center for Global Health and Medicine Kohnodai Hospital, Chiba, Japan.
BMJ Open. 2015 Jan 16;5(1):e006276. doi: 10.1136/bmjopen-2014-006276.
In spite of accumulating evidences suggesting an inverse association between insulin resistance and plasma B-type natriuretic peptide (BNP) levels, the effect of daily physical activity on plasma BNP in individuals with glucose intolerance remains unknown. We investigated the association of physical activity level (PAL) with plasma BNP in patients with impaired fasting glucose, impaired glucose tolerance and type 2 diabetes.
Cross-sectional study.
Outpatients visiting the National Center for Global Health and Medicine Kohnodai Hospital.
A total of 60 patients with glucose intolerance who did not take any hypoglycaemic agents, cholesterol-lowering agents and antihypertensive agents were recruited. Patients who were diagnosed as having heart failure and renal impairment, engaged in sports-like exercise and resistance training were excluded.
PAL was objectively measured by a triaxial accelerometer. The association between PAL and plasma BNP levels was assessed by multiple regression analysis.
PAL was positively correlated with plasma BNP levels (r=0.296, p=0.021). PAL was still significantly correlated with plasma BNP levels after adjustment for age (β=0.290, p=0.014), and adjustment for age and body mass index (β=0.282, p=0.018). Plasma BNP levels were inversely correlated with serum insulin levels (r=-0.350, p=0.006) and homeostasis model assessment-estimated insulin resistance (HOMA-IR; r=-0.363, p=0.004). Serum insulin levels (mean±SD, 8.1±6.4 μU/mL) and HOMA-IR (2.4±1.9) in the high-BNP group were significantly lower than those (11.2±7.4 μU/mL and 3.7±3.0, respectively) in the low-BNP group.
Our findings propose the possibility that plasma BNP may be increased by daily physical activity and BNP is associated with insulin resistance.
尽管有越来越多的证据表明胰岛素抵抗与血浆 B 型利钠肽（BNP）水平呈负相关，但在葡萄糖耐量受损个体中，日常体力活动对血浆 BNP 的影响尚不清楚。我们研究了体力活动水平（PAL）与空腹血糖受损、葡萄糖耐量受损和 2 型糖尿病患者血浆 BNP 的关系。
横断面研究。
日本国立全球健康与医疗中心 Kohnodai 医院门诊。
共纳入 60 名未服用任何降血糖药、降脂药和降压药的葡萄糖耐量受损患者。排除患有心力衰竭和肾功能不全、从事类似运动和抗阻训练的患者。
通过三轴加速度计客观测量 PAL。采用多元回归分析评估 PAL 与血浆 BNP 水平之间的关系。
PAL 与血浆 BNP 水平呈正相关（r=0.296，p=0.021）。调整年龄（β=0.290，p=0.014）和年龄及体重指数（β=0.282，p=0.018）后，PAL 仍与血浆 BNP 水平显著相关。血浆 BNP 水平与血清胰岛素水平（r=-0.350，p=0.006）和稳态模型评估-估计胰岛素抵抗（HOMA-IR；r=-0.363，p=0.004）呈负相关。高 BNP 组的血清胰岛素水平（均值±标准差，8.1±6.4 μU/mL）和 HOMA-IR（2.4±1.9）显著低于低 BNP 组（分别为 11.2±7.4 μU/mL 和 3.7±3.0）。
我们的研究结果表明，日常体力活动可能会导致血浆 BNP 升高，且 BNP 与胰岛素抵抗有关。
