Yuksel Mehmet Aytac, Alici Davutoglu Ebru, Temel Yuksel Ilkbal, Kucur Mine, Ekmekci Hakan, Balci Ekmekci Ozlem, Uludag Sezin, Uludag Seyfettin, Madazli Riza
a Department of Obstetrics and Gynecology , Cerrahpasa School of Medicine, Istanbul University , Istanbul , Turkey .
b Department of Obstetrics and Gynecology , Istanbul Okmeydani Research and Training Hospital , Istanbul , Turkey , and.
J Matern Fetal Neonatal Med. 2016;29(15):2527-30. doi: 10.3109/14767058.2015.1092958. Epub 2015 Oct 7.
The aim of the study is to evaluate maternal serum atrial natriuretic peptide (ANP) and brain-type natriuretic peptide (BNP) levels in patients with getational diabetes mellitus compared with a control group.
We have measured maternal serum ANP and BNP levels in 35 otherwise healthy and 45 gestational diabetic women between gestational week 24 and 28 referred to our unit in a cross-sectional study. Independent samples t-test or the Mann-Whitney U-test was used for comparison of two groups where appropriate.
Mean maternal serum homeostasis model assessment of insulin resistance (HOMA-IR), HbA1c, fasting glucose and insulin levels in gestational diabetes mellitus (GDM) group were significantly higher than the control group (p < 0.01). Mean maternal serum ANP and BNP levels of women with GDM were significantly lower than the control group (12.9 ± 9.9 versus 34.8 ± 16.9 pg/ml, p < 0.001; 416.6 ± 209.7 versus 629.7 ± 162.2 mg/dl, p < 0.001, respectively). Maternal serum ANP and BNP levels were negatively correlated with insulin levels, HbA1c and HOMA-IR values (p < 0.05).
Maternal serum ANP and BNP levels are significantly lower in patients with GDM. These biomarkers might be valuable in clinical setting for identifying high-risk women for developing diabetes during pregnancy.
本研究旨在评估妊娠期糖尿病患者与对照组相比母体血清心钠素（ANP）和脑钠肽（BNP）水平。
在一项横断面研究中，我们测量了转诊至我院的35名健康孕妇和45名妊娠期糖尿病孕妇在妊娠第24至28周时的母体血清ANP和BNP水平。在适当情况下，使用独立样本t检验或曼-惠特尼U检验对两组进行比较。
妊娠期糖尿病（GDM）组母体血清胰岛素抵抗稳态模型评估（HOMA-IR）、糖化血红蛋白（HbA1c）、空腹血糖和胰岛素水平的平均值显著高于对照组（p < 0.01）。GDM孕妇的母体血清ANP和BNP水平平均值显著低于对照组（分别为12.9±9.9与34.8±16.9 pg/ml，p < 0.001；416.6±209.7与629.7±162.2 mg/dl，p < 0.001）。母体血清ANP和BNP水平与胰岛素水平、HbA1c和HOMA-IR值呈负相关（p < 0.05）。
GDM患者的母体血清ANP和BNP水平显著降低。这些生物标志物在临床环境中对于识别孕期发生糖尿病的高危女性可能具有重要价值。
