Moon Yeonsil, Moon Won-Jin, Han Seol-Heui
Department of Neurology, Konkuk University Medical Center, Seoul, Republic of Korea.
Department of Radiology, Konkuk University School of Medicine, Seoul, Republic of Korea.
Am J Alzheimers Dis Other Demen. 2015 Aug;30(5):497-502. doi: 10.1177/1533317514566113. Epub 2015 Jan 16.
The insular cortex is associated with neuropsychiatric symptoms, changes in cardiovascular and autonomic control, and mortality in Alzheimer's dementia. However, the insular cortex does not provide information on the contribution of the other cortices to cognitive decline. We hypothesized that the factors that affect to atrophy in insular cortex are different from other cortical regions. A total of 42 patients with probable Alzheimer's dementia were included in the analyses. The manual drawing of regions of interest was used to detect insular cortex located in the deep gray matter and to avoid coatrophy. Covariates, which could affect to the atrophy of the cerebral cortex, were selected based on previous studies. Any of the demographic factors, vascular risk factors, and the severity scales of dementia was not associated with any insular volume ratio. We suggest that the pathomechanisms of atrophy in insular cortex are different from those of other cortex regions in Alzheimer's disease.
岛叶皮质与神经精神症状、心血管和自主神经控制的变化以及阿尔茨海默病性痴呆的死亡率相关。然而，岛叶皮质并未提供其他皮质对认知衰退影响的相关信息。我们假设影响岛叶皮质萎缩的因素与其他皮质区域不同。共有42例可能患有阿尔茨海默病性痴呆的患者纳入分析。通过手动绘制感兴趣区域来检测位于深部灰质中的岛叶皮质，并避免皮质萎缩。根据先前的研究选择可能影响大脑皮质萎缩的协变量。任何人口统计学因素、血管危险因素和痴呆严重程度量表均与任何岛叶体积比无关。我们认为，在阿尔茨海默病中，岛叶皮质萎缩的发病机制与其他皮质区域不同。
